CHAPTER 7: MicroRNAs in Ischemic Stroke, Hemorrhagic Stroke, and Traumatic Brain Injury

MicroRNAs (miRNAs) serve essential roles in virtually every aspect of brain function, including neurogenesis, neural development, and cellular responses leading to changes in synaptic plasticity. They are also implicated in neurodegeneration and neurological disorders, in responses to hypoxia and ischemia, and in ischemic tolerance induced by ischemic preconditioning. This chapter presents the findings in human and experimental animal studies of alterations in miRNAs associated with ischemic and hemorrhagic stroke and traumatic brain injury, and identifies potential therapeutic targets.