Metal-based Anticancer Agents
Metal-based anticancer drugs are among the most successful therapeutic agents, as evidenced by the frequent prescription of selected platinum and arsenic compounds to patients. Metal-based Anticancer Agents covers the interdisciplinary world of inorganic drug discovery and development by introducing the most prominent compound classes based on different transition metals, discussing emerging concepts and enabling methods, as well as presenting key pre-clinical and clinical aspects. Recent progress on the unique features of next-generation targeted metal-based anticancer agents, including supramolecular coordination complexes used for both therapy and drug delivery, promise a bright future beyond the benefits of pure cytotoxic activity. With contributions from global leaders in the field, this book will serve as a useful reference to established researchers as well as a practical guide to those new to metallodrugs, and postgraduate students of medicinal chemistry and metallobiology.
Metal-based Anticancer Agents, The Royal Society of Chemistry, 2019.
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CHAPTER 1: Enhancing the Therapeutic Potential of Platinum-based Anticancer Agents by Incorporating Clinically Approved Drugs as Ligandsp1-30ByReece G. Kenny;Reece G. KennyCentre for Synthesis and Chemical Biology, Department of Chemistry, Royal College of Surgeons in Ireland123 St. Stephen's GreenDublin 2Ireland[email protected]Search for other works by this author on:Celine J. MarmionCeline J. MarmionCentre for Synthesis and Chemical Biology, Department of Chemistry, Royal College of Surgeons in Ireland123 St. Stephen's GreenDublin 2Ireland[email protected]Search for other works by this author on:
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CHAPTER 2: Ruthenium, Osmium and Iridium in the Fight Against Cancerp31-61ByIsolda Romero-CanelónIsolda Romero-CanelónSchool of Pharmacy, Institute of Clinical Sciences, University of BirminghamBirmingham B15 2TTUK[email protected]Search for other works by this author on:
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CHAPTER 3: Iron Compounds as Anticancer Agentsp62-90ByAnne VessieresAnne VessieresSorbonne Université, CNRS, Institut Parisien de Chimie Moléculaire, UMR CNRS 82324, Place JussieuF-75005 ParisFrance[email protected]Search for other works by this author on:
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CHAPTER 4: Recent Advances in Anticancer Copper Compoundsp91-119ByAndrew Kellett;Andrew KellettSchool of Chemical Sciences and National Institute for Cellular Biotechnology, Dublin City UniversityGlasnevinDublin 9Ireland[email protected]Search for other works by this author on:Zara Molphy;Zara MolphySchool of Chemical Sciences and National Institute for Cellular Biotechnology, Dublin City UniversityGlasnevinDublin 9Ireland[email protected]Search for other works by this author on:Vickie McKee;Vickie McKeeSchool of Chemical Sciences and National Institute for Cellular Biotechnology, Dublin City UniversityGlasnevinDublin 9Ireland[email protected]Department of Physics, Chemistry and Pharmacy, University of Southern DenmarkCampusvej 555230 Odense MDenmarkSearch for other works by this author on:Creina SlatorCreina SlatorSchool of Chemical Sciences and National Institute for Cellular Biotechnology, Dublin City UniversityGlasnevinDublin 9Ireland[email protected]Search for other works by this author on:
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CHAPTER 5: Anticancer Gold Compoundsp120-142ByDi Hu;Di HuDepartment of Chemistry and State Key Laboratory of Synthetic Chemistry, The University of Hong KongPokfulam RoadHong KongChina[email protected]Search for other works by this author on:Chun-Nam Lok;Chun-Nam LokDepartment of Chemistry and State Key Laboratory of Synthetic Chemistry, The University of Hong KongPokfulam RoadHong KongChina[email protected]Search for other works by this author on:Chi-Ming CheChi-Ming CheDepartment of Chemistry and State Key Laboratory of Synthetic Chemistry, The University of Hong KongPokfulam RoadHong KongChina[email protected]Search for other works by this author on:
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CHAPTER 6: Heterometallic Complexes as Anticancer Agentsp143-168ByNatalia Curado;Natalia CuradoDepartment of Chemistry, Brooklyn College, The City University of New YorkBrooklynNY11210USA[email protected]Search for other works by this author on:Maria ContelMaria ContelDepartment of Chemistry, Brooklyn College, The City University of New YorkBrooklynNY11210USA[email protected]Chemistry PhD Program, The Graduate Center, The City University of New York365 Fifth AvenueNew YorkNY10016USABiochemistry PhD Program, The Graduate Center, The City University of New York365 Fifth AvenueNew YorkNY10016USABiology PhD Program, The Graduate Center, The City University of New York365 Fifth AvenueNew YorkNY10016USACancer Biology Program, University of Hawaii Cancer Center, University of Hawaii at ManoaHonoluluUSASearch for other works by this author on:
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CHAPTER 7: Vanadium Compounds as Enzyme Inhibitors with a Focus on Anticancer Effectsp169-195ByDebbie C. Crans;Debbie C. CransColorado State University, Cell and Molecular BiologyFort CollinsCO 80525USASearch for other works by this author on:Noah E. Barkley;Noah E. BarkleyColorado State University, Molecular and Cellular Integrative Neuroscience ProgramFort CollinsCO 80525USASearch for other works by this author on:Liliana Montezinho;Liliana MontezinhoCenter for Investigation Vasco da Gama (CIVG), Department of Veterinary Medicine, Escola Universitária Vasco da GamaCoimbraPortugalSearch for other works by this author on:M. Margarida CastroM. Margarida CastroUniversity of Coimbra, Department of Life Sciences, Faculty of Science and Technology3000-456 CoimbraPortugal[email protected]University of Coimbra, Coimbra Chemistry Center3000-456 CoimbraPortugalSearch for other works by this author on:
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CHAPTER 8: Arsenic-based Anticancer Agentsp196-214ByStéphane GibaudStéphane GibaudEA3452 Cibles thérapeutiques, formulation et Evaluation Préclinique du Médicament (CITHEFOR), Université de Lorraine, Faculté de Pharmacie5, rue Albert Lebrun54000 NancyFrance[email protected]Search for other works by this author on:
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CHAPTER 9: Supramolecular Metal-based Structures for Applications in Cancer Therapyp215-245ByMargot N. Wenzel;Margot N. WenzelSchool of Chemistry, Cardiff UniversityMain Building, Park PlaceCardiff CF10 3ATUnited Kingdom[email protected]Search for other works by this author on:Benjamin Woods;Benjamin WoodsSchool of Chemistry, Cardiff UniversityMain Building, Park PlaceCardiff CF10 3ATUnited Kingdom[email protected]Search for other works by this author on:Angela CasiniAngela CasiniSchool of Chemistry, Cardiff UniversityMain Building, Park PlaceCardiff CF10 3ATUnited Kingdom[email protected]Search for other works by this author on:
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CHAPTER 10: Enabling Methods to Elucidate the Effects of Metal-based Anticancer Agentsp246-270ByD. Kreutz;D. KreutzUniversity of Vienna, Department of Analytical ChemistryWaehringer Str. 381090 ViennaAustria[email protected][email protected]Search for other works by this author on:C. Gerner;C. GernerUniversity of Vienna, Department of Analytical ChemistryWaehringer Str. 381090 ViennaAustria[email protected][email protected]Search for other works by this author on:S. M. Meier-MenchesS. M. Meier-MenchesUniversity of Vienna, Department of Analytical ChemistryWaehringer Str. 381090 ViennaAustria[email protected][email protected]Search for other works by this author on:
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CHAPTER 11: Metal-based Radiotherapeuticsp271-307ByJason S. LewisJason S. LewisMolecular Pharmacology Program, Memorial Sloan Kettering Cancer CenterNew YorkNY10065USAWeill Cornell Medical CollegeNew YorkNY10065USASearch for other works by this author on:
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CHAPTER 12: Challenges and Chances in the Preclinical to Clinical Translation of Anticancer Metallodrugsp308-347ByIsabella Pötsch;Isabella PötschUniversity of Vienna, Department of Inorganic ChemistryWähringerstrasseVienna1090AustriaMedical University of Vienna, Institute of Cancer Research and Comprehensive Cancer Center, Department of Medicine IBorschkegasse 8a1090 ViennaAustria[email protected]Search for other works by this author on:Dina Baier;Dina BaierUniversity of Vienna, Department of Inorganic ChemistryWähringerstrasseVienna1090AustriaMedical University of Vienna, Institute of Cancer Research and Comprehensive Cancer Center, Department of Medicine IBorschkegasse 8a1090 ViennaAustria[email protected]Search for other works by this author on:Bernhard K. Keppler;Bernhard K. KepplerUniversity of Vienna, Department of Inorganic ChemistryWähringerstrasseVienna1090AustriaSearch for other works by this author on:Walter BergerWalter BergerMedical University of Vienna, Institute of Cancer Research and Comprehensive Cancer Center, Department of Medicine IBorschkegasse 8a1090 ViennaAustria[email protected]Search for other works by this author on:
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