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Non-coding RNA (ncRNA) have been described to take part in several molecular pathways regulating cell functions. Hence, they have been postulated as possible therapeutic targets and mediators in several diseases. Regarding multiple sclerosis, they have been described to be involved in the regulation of the immune response and in remyelination. In this chapter, the role of ncRNA in inflammation and remyelination will be addressed, focusing on their therapeutic potential for multiple sclerosis.

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