Skip Nav Destination
Biomaterials Science Series
Decellularized Extracellular Matrix: Characterization, Fabrication and Applications
Edited by
Tetsuji Yamaoka;
Tetsuji Yamaoka
National Cerebral and Cardiovascular Center Research Institute (NCVC), Japan
Search for other works by this author on:
Takashi Hoshiba
Takashi Hoshiba
Tokyo Metropolitan Industrial Technology Research Institute, Japan
Search for other works by this author on:
Hardback ISBN:
978-1-78801-467-0
PDF ISBN:
978-1-78801-599-8
EPUB ISBN:
978-1-83916-126-1
Special Collection:
2019 ebook collection
Series:
Biomaterials Science Series
No. of Pages:
352
Publication date:
05 Dec 2019
About this book
The extracellular matrix (ECM) supports cells and regulates various cellular functions in our body. The native ECM promises to provide an excellent scaffold for regenerative medicine. In order to use the ECM as a scaffold in medicine, its cellular fractions need to be removed while retaining its structural and compositional properties. This process is called decellularization, and the resulting product is known as the decellularized extracellular matrix (dECM). This book focuses on the sources of dECM and its preparation, characterization techniques, fabrication, and applications in regenerative medicine and biological studies. Using this book, the reader will gain a good foundation in the field of ECM decellularization complemented with a broad overview of dECM characterization, ranging from structural observation and compositional assessment to immune responses against dECM and applications, ranging from microfabrication and 3D-printing to the application of tissue-derived dECM in vascular grafts and corneal tissue engineering etc. The book closes with a section dedicated to cultured cell dECM, a complementary technique of tissue-derived dECM preparation, for application in tissue engineering and regenerative medicine, addressing its use in stem cell differentiation and how it can help in the study of the tumor microenvironment as well as in clinical trials of peripheral nerve regeneration.
Decellularized Extracellular Matrix: Characterization, Fabrication and Applications
Edited by: Tetsuji Yamaoka, Takashi Hoshiba
DOI: https://doi.org/10.1039/9781788015998
ISBN (print): 978-1-78801-467-0
Publisher: The Royal Society of Chemistry
Published: 2019
Download citation file:
Digital access
$220.00
Print format
Decellularized Extracellular Matrix
$220.00
Table of contents
-
CHAPTER 1: Extracellular Matrix Scaffolds for Tissue Engineering and Biological Researchp1-14ByTakashi Hoshiba;Takashi HoshibaBiotechnology Group, Tokyo Metropolitan Industrial Technology Research Institute2-4-10 AomiKoto-kuTokyo 135-0064Japanhoshiba.takashi@iri-tokyo.jpNational Institute for Materials Science1-1 NamikiTsukubaIbaraki 305-0044JapanSearch for other works by this author on:Tetsuji YamaokaTetsuji YamaokaDepartment of Biomedical Engineering, National Cerebral and Cardiovascular Center Research Institute6-1 Kishibe ShinmachiSuitaOsaka 564-8565Japanyamtet@ncvc.go.jpSearch for other works by this author on:
-
CHAPTER 2: Preparation Methods for Tissue/Organ-derived dECMs – Effects on Cell Removal and ECM Changesp15-28ByTetsuji YamaokaTetsuji YamaokaDepartment of Biomedical Engineering, National Cerebral and Cardiovascular Center Research Institute5-6-1 Kishibe Hon'machiSuitaOsaka 564-8565Japanyamtet@ncvc.go.jpSearch for other works by this author on:
-
CHAPTER 3: Preparation of Cultured Cell-derived Decellularized Matrix (dECM) – Factors Influencing dECM Formation and Its Abilityp29-50ByT. Hoshiba;T. HoshibaBiotechnology Group, Tokyo Metropolitan Industrial Technology Research Institute2-4-10 AomiKotokuTokyo 135-0064Japanhoshiba.takashi@iri-tokyo.jpSearch for other works by this author on:N. Kawazoe;N. KawazoeResearch Center for Functional Materials, National Institute for Materials Science1-1 NamikiTsukubaIbaraki 305-0044JapanSearch for other works by this author on:G. ChenG. ChenResearch Center for Functional Materials, National Institute for Materials Science1-1 NamikiTsukubaIbaraki 305-0044JapanSearch for other works by this author on:
-
CHAPTER 4: Bared Basement Membrane Substrata: Design, Cellular Assembly, Decellularization and Application to Tissue Regeneration and Stem Cell Differentiationp51-76ByReiko Nagano;Reiko NaganoEarth-Life Science Institute, Tokyo Institute of TechnologyOokayamaTokyo 152-8550JapanSearch for other works by this author on:Yukiko Toya-NakajimaYukiko Toya-NakajimaSearch for other works by this author on:
-
CHAPTER 5: A Novel Treatment for Giant Congenital Melanocytic Nevi Combining Inactivated Nevus Tissue by Pressurization and Cultured Epidermal Autograftp77-94ByNaoki Morimoto;Naoki MorimotoDepartment of Plastic and Reconstructive Surgery, Graduate School of Medicine, Kyoto University54 Kawahara-cho ShogoinSakyo-kuKyotoJapanmnaoki22@kuhp.kyoto-u.ac.jpSearch for other works by this author on:Atsushi Mahara;Atsushi MaharaDepartment of Biomedical Engineering, National Cerebral and Cardiovascular Center Research InstituteSuitaJapanSearch for other works by this author on:Tetsuji YamaokaTetsuji YamaokaDepartment of Biomedical Engineering, National Cerebral and Cardiovascular Center Research InstituteSuitaJapanSearch for other works by this author on:
-
CHAPTER 6: Immune Responses to Decellularized Matricesp95-115ByAlexandra Scanameo;Alexandra ScanameoCase Western Reserve University, Department of Pathology, Wolstein Research Building #51262103 Cornell RoadClevelandOhio 44106-7288USASearch for other works by this author on:Nicholas P. ZiatsNicholas P. ZiatsCase Western Reserve University, Departments of Pathology, Biomedical Engineering and Anatomy, Wolstein Research Building #51262103 Cornell RoadClevelandOhio 44106-7288USAnpz@case.eduSearch for other works by this author on:
-
CHAPTER 7: Decellularized Extracellular Matrix Hydrogels: Fabrication, Properties, Characterization, and Current Applicationsp116-138ByPamela Duran;Pamela DuranDepartment of Bioengineering and Sanford Consortium for Regenerative Medicine, University of CaliforniaSan DiegoCaliforniaUSAchristman@eng.ucsd.eduSearch for other works by this author on:Marianna Alperin;Marianna AlperinDepartment of Obstetrics, Gynecology, and Reproductive Sciences, Division of Female Pelvic Medicine and Reconstructive Surgery, University of CaliforniaSan DiegoCaliforniaUSASearch for other works by this author on:Karen L. ChristmanKaren L. ChristmanDepartment of Bioengineering and Sanford Consortium for Regenerative Medicine, University of CaliforniaSan DiegoCaliforniaUSAchristman@eng.ucsd.eduSearch for other works by this author on:
-
CHAPTER 8: Decellularized Extracellular Matrix as Bioink for 3D-Bioprintingp139-162BySanskrita Das;Sanskrita DasPohang University of Science and Technology, Department of Creative IT EngineeringPohang37673Republic of Koreajinahjang@postech.ac.krSearch for other works by this author on:Anthony Safaa Mukhtar;Anthony Safaa MukhtarResearch Institute of T&R Biofab Co. Ltd.Siheung-siGyeonggi-do15073Republic of Koreahappyshim@kpu.ac.krSearch for other works by this author on:Jinah Jang;Jinah JangPohang University of Science and Technology, Department of Creative IT EngineeringPohang37673Republic of Koreajinahjang@postech.ac.krPohang University of Science and Technology, School of Interdisciplinary Bioscience and Bioengineering (IBIO)37673Republic of KoreaSearch for other works by this author on:Jin-Hyung ShimJin-Hyung ShimResearch Institute of T&R Biofab Co. Ltd.Siheung-siGyeonggi-do15073Republic of Koreahappyshim@kpu.ac.krKorea Polytechnic University, Department of Mechanical EngineeringSiheung-siGyeonggi-do15073Republic of KoreaSearch for other works by this author on:
-
CHAPTER 9: Mechanical Property Tunable dECM and Their Regenerative Applicationsp163-178ByMintai P. Hwang;Mintai P. HwangMeinig School of Biomedical Engineering, Cornell UniversityIthacaNY 14853USACenter for Biomaterials, Biomedical Research Institute, Korea Institute of Science and Technology (KIST)Seoul 02792Republic of Koreakpark@kist.re.krSearch for other works by this author on:Kwideok ParkKwideok ParkCenter for Biomaterials, Biomedical Research Institute, Korea Institute of Science and Technology (KIST)Seoul 02792Republic of Koreakpark@kist.re.krSearch for other works by this author on:
-
CHAPTER 10: Use of Small Intestinal Submucosa dECM in Tissue Engineering and Regenerative Medicinep179-198ByJ. P. HoddeJ. P. HoddeDirector of Medical Sciences, Cook Biotech Incorporated1425 Innovation PlaceWest LafayetteINUSAJason.Hodde@cookbiotech.comSearch for other works by this author on:
-
CHAPTER 11: Small-diameter Acellular Vascular Grafts: From Basic Research to Clinical Applicationp199-218ByAtsushi Mahara;Atsushi MaharaDepartment of Biomedical Engineering, National Cerebral and Cardiovascular Center Research Institute5-7-1, FujishirodaiSuitaOsakaJapanyamtet@ncvc.go.jpSearch for other works by this author on:Tetsuji YamaokaTetsuji YamaokaDepartment of Biomedical Engineering, National Cerebral and Cardiovascular Center Research Institute5-7-1, FujishirodaiSuitaOsakaJapanyamtet@ncvc.go.jpSearch for other works by this author on:
-
CHAPTER 12: Decellularized Matrix for Corneal Tissue Engineering: Recent Advances in Development and Clinical Potentialp219-236ByY. Hashimoto;Y. HashimotoTokyo Medical and Dental University, Institute of Biomaterials and Bioengineering, Department of Material-based Medical Engineering2-3-10, Kanda-SurugadaiChiyoda-kuTokyo 101-0062Japankishida.mbme@tmd.ac.jpSearch for other works by this author on:S. Funamoto;S. FunamotoTokyo Medical and Dental University, Institute of Biomaterials and Bioengineering, Department of Material-based Medical Engineering2-3-10, Kanda-SurugadaiChiyoda-kuTokyo 101-0062Japankishida.mbme@tmd.ac.jpNational Institute for Materials Science, International Center for Materials Nanoarchitectonics1-2-1, SengenTsukuba-cityIbaraki305-0047JapanSearch for other works by this author on:S. Sasaki;S. SasakiTokyo Medical and Dental University, Department of Ophthalmology1-5-45, YushimaBunkyo-kuTokyo 113-8510JapanSearch for other works by this author on:T. Kimura;T. KimuraTokyo Medical and Dental University, Institute of Biomaterials and Bioengineering, Department of Material-based Medical Engineering2-3-10, Kanda-SurugadaiChiyoda-kuTokyo 101-0062Japankishida.mbme@tmd.ac.jpSearch for other works by this author on:H. Kobayashi;H. KobayashiNational Institute for Materials Science, International Center for Materials Nanoarchitectonics1-2-1, SengenTsukuba-cityIbaraki305-0047JapanSearch for other works by this author on:A. KishidaA. KishidaTokyo Medical and Dental University, Institute of Biomaterials and Bioengineering, Department of Material-based Medical Engineering2-3-10, Kanda-SurugadaiChiyoda-kuTokyo 101-0062Japankishida.mbme@tmd.ac.jpSearch for other works by this author on:
-
CHAPTER 13: Engineering an Endocrine Neo-Pancreasp237-258ByEriselda Keshi;Eriselda KeshiCharité – Universitätsmedizin Berlin, Department of Surgery, Campus Charité Mitte I Campus Virchow Klinikum, Experimental SurgeryAugustenburger Platz 113353 BerlinGermanyigor.sauer@charite.deSearch for other works by this author on:Igor M. Sauer;Igor M. SauerCharité – Universitätsmedizin Berlin, Department of Surgery, Campus Charité Mitte I Campus Virchow Klinikum, Experimental SurgeryAugustenburger Platz 113353 BerlinGermanyigor.sauer@charite.deSearch for other works by this author on:Karl H. HillebrandtKarl H. HillebrandtCharité – Universitätsmedizin Berlin, Department of Surgery, Campus Charité Mitte I Campus Virchow Klinikum, Experimental SurgeryAugustenburger Platz 113353 BerlinGermanyigor.sauer@charite.deSearch for other works by this author on:
-
CHAPTER 14: Decellularized Cell-Secreted Matrices: Novel Materials for Superior Stem Cell Expansion and Tissue Engineeringp259-285ByMichael C. Yang;Michael C. YangDepartment of Biomedical Engineering, Particulate Fluids Processing Centre, University of MelbourneParkville VIC 3010Australiadaniel.heath@unimelb.edu.auDepartment of Maternal-Fetal Medicine Pregnancy Research Centre, Royal Women's HospitalParkvilleVictoriaAustraliaSearch for other works by this author on:Bill Kalionis;Bill KalionisDepartment of Maternal-Fetal Medicine Pregnancy Research Centre, Royal Women's HospitalParkvilleVictoriaAustraliaUniversity of Melbourne Department of Obstetrics and Gynaecology, Royal Women's HospitalParkvilleVictoriaAustraliaSearch for other works by this author on:Daniel E. HeathDaniel E. HeathDepartment of Biomedical Engineering, Particulate Fluids Processing Centre, University of MelbourneParkville VIC 3010Australiadaniel.heath@unimelb.edu.auSearch for other works by this author on:
-
CHAPTER 15: Decellularized Extracellular Matrix for the Regulation of Stem Cell Differentiationp286-304ByT. HoshibaT. HoshibaTokyo Metropolitan Industrial Technology Research Institute2-4-10 AomiKoto-kuTokyo135-0064Japanhoshiba.takashi@iri-tokyo.jpResearch Center for Functional Materials, National Institute for Materials Science1-1 NamikiTsukubaIbaraki 305-0044JapanSearch for other works by this author on:
-
CHAPTER 16: Fibroblastic Cell-derived Extracellular Matrices: A Cell Culturing System to Model Key Aspects of the Tumor Microenvironmentp305-327ByJ. C. Gardiner;J. C. GardinerCancer Biology, Martin and Concetta Greenberg Pancreatic Cancer Institute, Fox Chase Cancer CenterPhiladelphiaPA 19111USAedna.cukierman@fccc.eduednacukierman@gmail.comSearch for other works by this author on:K. S. Raghavan;K. S. RaghavanCancer Biology, Martin and Concetta Greenberg Pancreatic Cancer Institute, Fox Chase Cancer CenterPhiladelphiaPA 19111USAedna.cukierman@fccc.eduednacukierman@gmail.comSearch for other works by this author on:J. I. Alexander;J. I. AlexanderCancer Biology, Martin and Concetta Greenberg Pancreatic Cancer Institute, Fox Chase Cancer CenterPhiladelphiaPA 19111USAedna.cukierman@fccc.eduednacukierman@gmail.comSearch for other works by this author on:J. Franco-Barraza;J. Franco-BarrazaCancer Biology, Martin and Concetta Greenberg Pancreatic Cancer Institute, Fox Chase Cancer CenterPhiladelphiaPA 19111USAedna.cukierman@fccc.eduednacukierman@gmail.comSearch for other works by this author on:E. CukiermanE. CukiermanCancer Biology, Martin and Concetta Greenberg Pancreatic Cancer Institute, Fox Chase Cancer CenterPhiladelphiaPA 19111USAedna.cukierman@fccc.eduednacukierman@gmail.comSearch for other works by this author on:
-
CHAPTER 17: Extracellular Matrix in Peripheral Nerve Regenerationp328-345BySheng Yi;Sheng YiKey Laboratory of Neuroregeneration of Jiangsu and Ministry of Education, Co-innovation Center of Neuroregeneration, Nantong University19 Qixiu RoadNantongJiangsuChinanervegu@ntu.edu.cnSearch for other works by this author on:Lingchi Xu;Lingchi XuKey Laboratory of Neuroregeneration of Jiangsu and Ministry of Education, Co-innovation Center of Neuroregeneration, Nantong University19 Qixiu RoadNantongJiangsuChinanervegu@ntu.edu.cnSearch for other works by this author on:Yumin Yang;Yumin YangKey Laboratory of Neuroregeneration of Jiangsu and Ministry of Education, Co-innovation Center of Neuroregeneration, Nantong University19 Qixiu RoadNantongJiangsuChinanervegu@ntu.edu.cnSearch for other works by this author on:Xiaosong GuXiaosong GuKey Laboratory of Neuroregeneration of Jiangsu and Ministry of Education, Co-innovation Center of Neuroregeneration, Nantong University19 Qixiu RoadNantongJiangsuChinanervegu@ntu.edu.cnSearch for other works by this author on:
Spotlight
Advertisement
Advertisement
