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Coffee is one of the most widely used beverages in the world. It includes a wide array of components that can have potential implications for liver health. Epidemiological and experimental studies have demonstrated the positive effects of coffee on several liver diseases. Coffee consumption is associated with the prevention of hepatic steatosis and fibrosis, and a reduction in cirrhosis and the risk of hepatocellular carcinoma (HCC). Experimental studies show that coffee consumption reduces fat accumulation and collagen deposition in the liver and promotes antioxidant capacity through an increase in glutathione as well as modulation of protein expression of several proinflammatory (IL-1, TNF-α) and profibrotic (transforming growth factor-β, connective tissue growth factor, alpha smooth muscle actin) mediators. Several studies indicate that among other compounds, cafestol and kahweol may operate by modulating multiple enzymes involved in the detoxification process of carcinogens causing HCC. Increasing evidence has been accumulated on the beneficial effect of coffee in the liver, thus, although it is premature to prescribe coffee as a medication, it should be recommended as an adjuvant for liver disease treatment.

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