Flow Chemistry: Integrated Approaches for Practical Applications
Historically pharmaceutical and fine chemical products have been synthesised using batch methods, but increasingly chemists are looking towards flow chemistry as a greener and more efficient alternative. In flow chemistry reactions are performed in a reactor with the reactants pumped through it. It has the benefit of being easily scaled up and it is straightforward to integrate synthesis, workup and analysis into one system. Flow chemistry is considered a greener alternative to batch chemistry because it is easier to control and minimise hazardous intermediates and by-products. There is significant interest in the use of flow chemistry both in the lab and on an industrial scale.
Flow Chemistry provides an update on recent advances that have been made in the field. Particular emphasis is given to the new integrated approaches that bring together several elements to implement flow processes as a regular green chemistry tool for the chemical industries. With chapter contributions from several well-known experts in the field, this book is a valuable resource for researchers working in green chemistry and synthesis, chemical engineers and industrial chemists working in the pharmaceutical and fine chemicals industries.
Flow Chemistry: Integrated Approaches for Practical Applications, The Royal Society of Chemistry, 2019.
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Table of contents
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Chapter 1: Recent Perspectives in Catalysis under Continuous Flowp1-49ByHaruro Ishitani;Haruro IshitaniGreen & Sustainaible Chemistry Cooperation Laboratory, Graduate School of Science, The University of TokyoHongo, Bunkyo-kuTokyo 113-0033Japanshu_kobayashi@chem.s.u-tokyo.ac.jpSearch for other works by this author on:Yuki Saito;Yuki SaitoDepartment of Chemistry, School of Science, The University of TokyoHongo, Bunkyo-kuTokyo 113-0033JapanSearch for other works by this author on:Benjamin Laroche;Benjamin LarocheDepartment of Chemistry, School of Science, The University of TokyoHongo, Bunkyo-kuTokyo 113-0033JapanSearch for other works by this author on:Xiaofeng Rao;Xiaofeng RaoDepartment of Chemistry, School of Science, The University of TokyoHongo, Bunkyo-kuTokyo 113-0033JapanSearch for other works by this author on:Shū KobayashiShū KobayashiGreen & Sustainaible Chemistry Cooperation Laboratory, Graduate School of Science, The University of TokyoHongo, Bunkyo-kuTokyo 113-0033Japanshu_kobayashi@chem.s.u-tokyo.ac.jpDepartment of Chemistry, School of Science, The University of TokyoHongo, Bunkyo-kuTokyo 113-0033JapanSearch for other works by this author on:
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Chapter 2: Green Biotransformations under Flow Conditionsp50-85ByEduardo Garcia-Verdugo;Eduardo Garcia-VerdugoDepartamento de Química Inorgánica y Orgánica, Universidad Jaume IAvda, Sos Baynat s/n, E-12071CastellonSpaincepeda@uji.esluiss@uji.esSearch for other works by this author on:Raúl Porcar;Raúl PorcarDepartamento de Química Inorgánica y Orgánica, Universidad Jaume IAvda, Sos Baynat s/n, E-12071CastellonSpaincepeda@uji.esluiss@uji.esSearch for other works by this author on:Santiago V. Luis;Santiago V. LuisDepartamento de Química Inorgánica y Orgánica, Universidad Jaume IAvda, Sos Baynat s/n, E-12071CastellonSpaincepeda@uji.esluiss@uji.esSearch for other works by this author on:Pedro LozanoPedro LozanoDepartamento de Bioquímica y Biología Molecular “B” e Inmunología, Facultad de Química, Campus de Excelencia Internacional Regional “Campus Mare Nostrum”, Universidad de MurciaE-30100MurciaSpainplozanor@um.esSearch for other works by this author on:
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Chapter 3: Organometallic Chemistry in Flow in the Pharmaceutical Industryp86-128ByE. Palao;E. PalaoDiscovery Sciences, Janssen Research and Development, Janssen-Cilag, S.A.Jarama 75A45007 ToledoSpainjalcazar@its.jnj.comSearch for other works by this author on:J. AlcazarJ. AlcazarDiscovery Sciences, Janssen Research and Development, Janssen-Cilag, S.A.Jarama 75A45007 ToledoSpainjalcazar@its.jnj.comSearch for other works by this author on:
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Chapter 4: Perspectives on the Use of Flow Systems to Carry Out Organic Photochemical Reactionsp129-152ByK. Mizuno;K. MizunoNara Institute of Science and Technology (NAIST)Takayama-choIkomaNara 630-0192Japankmizunophotochem@gmail.comSearch for other works by this author on:K. KakiuchiK. KakiuchiNara Institute of Science and Technology (NAIST)Takayama-choIkomaNara 630-0192Japankmizunophotochem@gmail.comSearch for other works by this author on:
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Chapter 5: Electrochemistry under Flow Conditionsp153-198ByAna A. Folgueiras-Amador;Ana A. Folgueiras-AmadorDepartment of Chemistry, University of Southampton, HighfieldSouthamptonSO17 1BJUKSearch for other works by this author on:T. WirthT. WirthSchool of Chemistry, Cardiff University, Park Place, Main BuildingCardiffCF10 3ATUKWirthT@cardiff.ac.ukSearch for other works by this author on:
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Chapter 6: Sustainable Approaches to C–H Functionalizations Through Flow Techniquesp199-216ByS. Santoro;S. SantoroLaboratory of Green S.O.C., Dipartimento di Chimica Biologia e Biotecnologie, Università di PerugiaVia Elce di Sotto8 – 06123 PerugiaItalyluigi.vaccaro@unipg.itSearch for other works by this author on:F. Ferlin;F. FerlinLaboratory of Green S.O.C., Dipartimento di Chimica Biologia e Biotecnologie, Università di PerugiaVia Elce di Sotto8 – 06123 PerugiaItalyluigi.vaccaro@unipg.itSearch for other works by this author on:L. VaccaroL. VaccaroLaboratory of Green S.O.C., Dipartimento di Chimica Biologia e Biotecnologie, Università di PerugiaVia Elce di Sotto8 – 06123 PerugiaItalyluigi.vaccaro@unipg.itSearch for other works by this author on:
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Chapter 7: Radical Polymerisation under Flow Conditionsp217-256ByIan R. BaxendaleIan R. BaxendaleSearch for other works by this author on:
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Chapter 8: Ionic Polymerisation and New Approaches to Polymerisation under Flow Conditionsp257-315ByIan R. BaxendaleIan R. BaxendaleSearch for other works by this author on:
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Chapter 9: Continuous Flow Synthesis of Nanomaterialsp316-339ByAmol A. Kulkarni;Amol A. KulkarniChemical Engineering & Process Development Division, CSIR-National Chemical LaboratoryDr. Homi Bhabha RoadPashan Pune – 411008Indiaaa.kulkarni@ncl.res.inSearch for other works by this author on:Rajashri B. JundaleRajashri B. JundaleChemical Engineering & Process Development Division, CSIR-National Chemical LaboratoryDr. Homi Bhabha RoadPashan Pune – 411008Indiaaa.kulkarni@ncl.res.inSearch for other works by this author on:
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Chapter 10: NMR Microcoils for On-line Reaction Monitoringp340-365ByM. V. Gomez;M. V. GomezUniversidad de Castilla-La Mancha, Instituto Regional de Investigación Científica AplicadaAvda Camilo Jose Cela, snCiudad Real13071Spainmariavictoria.gomez@uclm.esSearch for other works by this author on:A. H. VeldersA. H. VeldersUniversidad de Castilla-La Mancha, Instituto Regional de Investigación Científica AplicadaAvda Camilo Jose Cela, snCiudad Real13071Spainmariavictoria.gomez@uclm.esWageningen University, Laboratory of BioNanoTechnologyAxis, Bornse Weilanden 9Wageningen6709 WGThe NetherlandsSearch for other works by this author on:
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Chapter 11: Flow Chemistry Systems Based on Membranesp366-387ByJ. Sanchez-MarcanoJ. Sanchez-MarcanoInstitut Européen des Membranes, IEM, UMR 5635, Université de Montpelliercc 047, 2, Place Eugène, Bataillon34095MontpellierCedex 5Francejose.sanchez-marcano@umontpellier.frSearch for other works by this author on:
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Chapter 12: New Microreactor Designs for Practical Applications Realized by Additive Manufacturingp388-415ByP. LöbP. LöbFraunhofer Institute for Microengineering and Microsystems IMM, Division Energy and Chemical TechnologyCarl-Zeiss-Str. 18-2055129 MainzGermanypatrick.loeb@imm.fraunhofer.deSearch for other works by this author on:
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Chapter 13: Additively Manufactured Advanced Flow Reactors for Enhanced Heat and Mass Transferp416-439ByObinna Okafor;Obinna OkaforFaculty of Engineering, University of NottinghamNottinghamNG7 2RDUKvictor.sanssangorrin@nottingham.ac.ukSearch for other works by this author on:Ruth Goodridge;Ruth GoodridgeFaculty of Engineering, University of NottinghamNottinghamNG7 2RDUKvictor.sanssangorrin@nottingham.ac.ukSearch for other works by this author on:Victor SansVictor SansFaculty of Engineering, University of NottinghamNottinghamNG7 2RDUKvictor.sanssangorrin@nottingham.ac.ukInstitute of Advanced Materials (INAM), Universitat Jaume I12006SpainSearch for other works by this author on:
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Chapter 14: Integrated Microreaction Systems of Microdevices with Conventional Equipmentp440-460ByG. S. Luo;G. S. LuoTsinghua University, State Key Laboratory of Chemical Engineering, Department of Chemical EngineeringBeijing 100084Chinagsluo@tsinghua.edu.cnSearch for other works by this author on:J. Deng;J. DengTsinghua University, State Key Laboratory of Chemical Engineering, Department of Chemical EngineeringBeijing 100084Chinagsluo@tsinghua.edu.cnSearch for other works by this author on:K. WangK. WangTsinghua University, State Key Laboratory of Chemical Engineering, Department of Chemical EngineeringBeijing 100084Chinagsluo@tsinghua.edu.cnSearch for other works by this author on:
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Chapter 15: Automation of Flow Chemistryp461-484ByJonathan N. Jaworski;Jonathan N. JaworskiMassachusetts Institute of Technology, Department of Chemistry77 Massachusetts AvenueCambridgeMA02139 USAtfj@mit.eduSearch for other works by this author on:Rachel L. Beingessner;Rachel L. BeingessnerMassachusetts Institute of Technology, Department of Chemistry77 Massachusetts AvenueCambridgeMA02139 USAtfj@mit.eduSearch for other works by this author on:Timothy F. JamisonTimothy F. JamisonMassachusetts Institute of Technology, Department of Chemistry77 Massachusetts AvenueCambridgeMA02139 USAtfj@mit.eduSearch for other works by this author on:
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Chapter 16: Upscaling the Aza-Diels–Alder Reaction for Pharmaceutical Industrial Needs in Flow Chemistryp485-510ByR. Ferritto-CrespoR. Ferritto-CrespoSearch for other works by this author on:
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Chapter 17: Industrial Continuous-flow Chemistry under cGMP Conditionsp511-530ByRobert Moylan;Robert MoylanTechnical Services/Manufacturing Science, Eli Lilly LtdDunderrow, KinsaleCo.CorkIrelandmoylan_robert@lilly.comSearch for other works by this author on:Sharon Bourke;Sharon BourkeTechnical Services/Manufacturing Science, Eli Lilly LtdDunderrow, KinsaleCo.CorkIrelandmoylan_robert@lilly.comSearch for other works by this author on:Kevin Cole;Kevin ColeSmall Molecule Design and Development, Eli Lilly and CompanyIndianapolisIN 46285USASearch for other works by this author on:Scott MayScott MaySmall Molecule Design and Development, Eli Lilly and CompanyIndianapolisIN 46285USASearch for other works by this author on:
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