Flow Chemistry: Integrated Approaches for Practical Applications
Chapter 6: Sustainable Approaches to C–H Functionalizations Through Flow Techniques
Published:18 Sep 2019
Special Collection: 2019 ebook collection , ECCC Environmental eBooks 1968-2022Series: Green Chemistry
S. Santoro, F. Ferlin, and L. Vaccaro, in Flow Chemistry: Integrated Approaches for Practical Applications, ed. S. V. Luis and E. Garcia-Verdugo, The Royal Society of Chemistry, 2019, ch. 6, pp. 199-216.
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C–H functionalization reactions have attracted great attention in recent years due to their promise of simplifying organic synthetic pathways. However, many reported protocols suffer from common limitations, such as the usually harsh reaction conditions, with the related safety issues, and the requirement of high catalyst loadings. Recent research efforts have demonstrated that the application of flow technologies to C–H functionalization reactions can significantly mitigate these issues, also resulting in more sustainable protocols. In this chapter we present selected examples of C–H functionalizations realized in flow conditions, highlighting the sustainability aspects effected by the application of flow techniques.