CHAPTER 8: Mechanochemical Synthesis of Biologically Relevant Heterocycles

Mechanochemistry involves the application of mechanical energy to achieve chemical transformations. Since it is usually performed in solid state at room temperature, mechanochemistry is regarded as one of the pathways toward more sustainable synthetic chemistry. Furthermore, by working under solvent-free conditions, reagents are highly concentrated and solvation phenomena are not relevant, and the combination of these two factors often leads to accelerated reactions. This chapter provides an overview of the application of mechanochemical conditions to the synthesis of heterocycles, the compounds with the highest relevance for the pharmaceutical and agrochemical industries.