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Green Chemistry Series
Green Synthetic Processes and Procedures
Edited by
Roberto Ballini
Roberto Ballini
University of Camerino, Italy
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Hardback ISBN:
978-1-78801-512-7
PDF ISBN:
978-1-78801-613-1
EPUB ISBN:
978-1-78801-839-5
Series:
Green Chemistry
No. of Pages:
413
Publication date:
27 Jun 2019
Book Chapter
CHAPTER 3: Application of Step, Cumulative, and Global E-factor and Process Mass Intensity Metrics to Gauge Synthesis Efficiency: l-DOPA and Apixaban Pharmaceutical Examples
By
John Andraos
John Andraos
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Published:27 Jun 2019
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Series: Green Chemistry
Page range:
39 - 52
Citation
J. Andraos, in Green Synthetic Processes and Procedures, ed. R. Ballini, The Royal Society of Chemistry, 2019, pp. 39-52.
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The utility of step, cumulative, and global E-factor and process mass intensity metrics is demonstrated for the analysis of the material efficiency of synthesis plans for the pharmaceuticals l-DOPA and apixaban. The mathematical relationships relating global and cumulative metrics to step metrics are applicable to any synthesis plan for any molecule.
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