Nutritional Signaling Pathway Activities in Obesity and Diabetes
Chapter 4: Nutritional Regulation of Inflammation in Obesity and Diabetes
Published:24 Aug 2020
Special Collection: 2020 ebook collection
X. Wang and J. Liu, in Nutritional Signaling Pathway Activities in Obesity and Diabetes, ed. Z. Cheng, The Royal Society of Chemistry, 2020, ch. 4, pp. 71-93.
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For decades, the prevalence of obesity and Type 2 diabetes has been rising, becoming significant threats to human health worldwide. Accumulating evidence indicates that excess energy nutrition causes chronic low-grade tissue inflammation and finally contributes to systemic metabolic dysfunction, while various natural products such as polyphenols, alkaloids, terpenoids, and n3-polyunsaturated fatty acids exert anti-inflammatory benefits. As an energy reservoir, adipose tissue depots play a vital role in energy storage and inflammatory regulation. In this chapter, we will focus on adipose tissues and talk about the molecular and cellular mechanisms that link nutrition to obesity and diabetes, since we outline the natural products as strategies to combat these metabolic syndromes.