CHAPTER 8: Nanodiamonds and Their Biological Applications
Published:03 Feb 2021
C. P. Epperla, H. Lin, and H. Chang, in Carbon Nanostructures for Biomedical Applications, ed. T. Da Ros, N. Martín, and J. Nierengarten, The Royal Society of Chemistry, 2021, pp. 257-292.
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Nanomaterials integrated with modern nanotechnology are leading most of the interesting active research in the biomedical field right now. Among nanomaterials, nanodiamonds owe their fame to a unique set of outstanding properties, such as biocompatibility, chemical inertness, high surface area, tunable surface structure and excellent optical/mechanical properties. Due to their unique optical and spectroscopic properties, nanodiamonds have been studied in bioimaging and in super-resolution imaging studies. Nanodiamonds have been utilized for studies of the biodistribution and pharmacokinetics of therapeutic cells in a preclinical setting. Nanodiamonds have also been explored as a nanothermometer for the study of nanoscale chemical reactions due to their invariability to the local chemical environment. Additionally, the strategies for further improving gene delivery by nanodiamonds are reviewed. This chapter covers the recent progress in the biological applications of nanodiamonds and underlines the great advances made by the field, as well as the challenges still faced in achieving the translation of these techniques from the laboratory to the clinic.