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Chemical Biology
Inhibitors of Protein–Protein Interactions
Edited by
Ali Tavassoli
Ali Tavassoli
University of Southhampton, United Kingdom
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Hardback ISBN:
978-1-78801-569-1
PDF ISBN:
978-1-83916-067-7
EPUB ISBN:
978-1-83916-070-7
Special Collection:
2020 ebook collection
Series:
Chemical Biology
No. of Pages:
342
Published online:
25 Nov 2020
Published in print:
07 Dec 2020
Book Chapter
Chapter 6: Genetically Encoded SICLOPPS Libraries for the Identification of PPI Inhibitors
By
Ali Tavassoli
Ali Tavassoli
Search for other works by this author on:
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Published:25 Nov 2020
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Special Collection: 2020 ebook collectionSeries: Chemical Biology
Page range:
218 - 231
Citation
M. M. Fernholz, L. M. Windeln, M. Papayova, and A. Tavassoli, in Inhibitors of Protein–Protein Interactions, ed. A. Tavassoli, The Royal Society of Chemistry, 2020, ch. 6, pp. 218-231.
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Genetically encoded cyclic peptide libraries have caused a step-change in hit discovery against some of the most challenging disease targets. Split-intein circular ligation of peptides and proteins (SICLOPPS) enables intracellular generation of cyclic peptide libraries in prokaryotes and eukaryotes. Library production in cells allows functional, cell-based screening for inhibitor identification. Here, we review the use of SICLOPPS screening for the identification of protein–protein interaction inhibitors against a variety of targets.
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