Skip to Main Content
Skip Nav Destination

Several complementary approaches have been developed to discover modulators of protein–protein interactions (PPIs). This chapter provides a perspective on bioinformatic classifications of PPIs, which has led to a better understanding of which PPIs are more amenable to modulation. Next, workflows to target PPIs are outlined, including phenotypic screening and target-based approaches. Target-based approaches can be further categorized into structure-based design and target-based screening. The overview, benefits, and drawbacks of each workflow are discussed. Last, we illustrate two complementary computational methods to assess protein interfaces using the KIX protein.

You do not currently have access to this chapter, but see below options to check access via your institution or sign in to purchase.
Don't already have an account? Register
Close Modal

or Create an Account

Close Modal
Close Modal