Chapter 4: Identifying and Developing Small Molecule Inhibitors of Protein–Protein Interactions
Published:25 Nov 2020
R. S. Holvey, S. E. Dalton, T. D. Heightman, and D. C. Rees, in Inhibitors of Protein–Protein Interactions, ed. A. Tavassoli, The Royal Society of Chemistry, 2020, ch. 4, pp. 111-159.
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This chapter summarises some of the techniques used in the discovery and development of small molecule protein–protein interaction (PPI) inhibitors. A description of the key considerations is supported by a selection of case studies from the literature exploring different PPI targets and a range of hit-finding techniques. A table of selected examples of PPI inhibitors that have progressed into clinical trials is also given.