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Chemical Biology
Inhibitors of Protein–Protein Interactions
Edited by
Ali Tavassoli
Ali Tavassoli
University of Southhampton, United Kingdom
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Hardback ISBN:
978-1-78801-569-1
PDF ISBN:
978-1-83916-067-7
EPUB ISBN:
978-1-83916-070-7
Special Collection:
2020 ebook collection
Series:
Chemical Biology
No. of Pages:
342
Published online:
25 Nov 2020
Published in print:
07 Dec 2020
Book Chapter
Chapter 4: Identifying and Developing Small Molecule Inhibitors of Protein–Protein Interactions
By
Samuel E. Dalton
;
Samuel E. Dalton
Merck Sharp & Dohme
1st Floor, 2 Pancras Square
London
NC1 4AG
UK
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David C. Rees
David C. Rees
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-
Published:25 Nov 2020
-
Special Collection: 2020 ebook collectionSeries: Chemical Biology
Page range:
111 - 159
Citation
R. S. Holvey, S. E. Dalton, T. D. Heightman, and D. C. Rees, in Inhibitors of Protein–Protein Interactions, ed. A. Tavassoli, The Royal Society of Chemistry, 2020, ch. 4, pp. 111-159.
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This chapter summarises some of the techniques used in the discovery and development of small molecule protein–protein interaction (PPI) inhibitors. A description of the key considerations is supported by a selection of case studies from the literature exploring different PPI targets and a range of hit-finding techniques. A table of selected examples of PPI inhibitors that have progressed into clinical trials is also given.
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