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Chemical Biology
The Discovery and Utility of Chemical Probes in Target Discovery
Edited by
Saleta Vazquez Rodriguez
Saleta Vazquez Rodriguez
University of Oxford, UK
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Hardback ISBN:
978-1-78801-589-9
PDF ISBN:
978-1-83916-074-5
EPUB ISBN:
978-1-83916-084-4
Special Collection:
2020 ebook collection
Series:
Chemical Biology
No. of Pages:
326
Publication date:
17 Nov 2020
About this book
Numerous genetic methods can be utilised to link a phenotype to a single molecular target but annotated small molecule chemical probes and even entire chemogenomic libraries are increasingly being used as a complementary approach. This book will comprehensively cover the state of the art in chemical probes and best practice for use in target discovery, illustrated throughout with examples. Ideal for students and established biochemists, the book will also cover new technologies for probe discovery, new probe modalities, the new field of probes for RNA targets and the mature field of kinase chemical probes.
The Discovery and Utility of Chemical Probes in Target Discovery, The Royal Society of Chemistry, 2020.
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Digital access
$220.00
Print format
The Discovery and Utility of Chemical Probes in Target Discovery
$220.00
Table of contents
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CHAPTER 1: Introduction to Chemical Probesp1-13ByBridget K. WagnerBridget K. WagnerChemical Biology and Therapeutics Science Program, Broad Institute415 Main StreetCambridgeMA 02142USA[email protected]Search for other works by this author on:
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CHAPTER 2: DNA-encoded Chemistry and Its Use in Discovering Chemical Probesp14-38ByAnthony D. KeefeAnthony D. KeefeSearch for other works by this author on:
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CHAPTER 3: Computational Methods for the Discovery of Chemical Probesp39-68ByG. Poda;G. PodaLeslie Dan Faculty of Pharmacy, University of TorontoTorontoOntarioCanadaSearch for other works by this author on:V. TanchukV. TanchukV. P. Kukhar Institute of Bioorganic Chemistry and Petrochemistry, National Academy of Sciences of UkraineKyivUkraineSearch for other works by this author on:
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CHAPTER 4: Best Practices for Design and Characterization of Covalent Chemical Probesp69-99ByRonen Gabizon;Ronen GabizonDepartment of Organic Chemistry, Weizmann Institute of ScienceRehovot 7610001Israel[email protected]Search for other works by this author on:Efrat Resnick;Efrat ResnickDepartment of Organic Chemistry, Weizmann Institute of ScienceRehovot 7610001Israel[email protected]Search for other works by this author on:Nir LondonNir LondonDepartment of Organic Chemistry, Weizmann Institute of ScienceRehovot 7610001Israel[email protected]Search for other works by this author on:
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CHAPTER 5: Cyclic Peptides as Chemical Probesp100-123ByL. Serrano;L. SerranoUniversity of Oxford, Chemistry Research Laboratory12 Mansfield RoadOxford OX1 3TAUKSearch for other works by this author on:G. Roper;G. RoperUniversity of Oxford, Chemistry Research Laboratory12 Mansfield RoadOxford OX1 3TAUKSearch for other works by this author on:A. KawamuraA. KawamuraUniversity of Oxford, Chemistry Research Laboratory12 Mansfield RoadOxford OX1 3TAUKNewcastle University, School of Natural and Environmental Sciences, ChemistryBedson BuildingNewcastle upon Tyne NE1 7RUUK[email protected]Search for other works by this author on:
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CHAPTER 6: Discovery and Use of Natural Products and Derivatives as Chemical Probesp124-149ByMasaki Kita;Masaki KitaGraduate School of Bioagricultural Sciences, Nagoya UniversityFuro-cho, ChikusaNagoya 464-8601Japan[email protected]Search for other works by this author on:Hideo KigoshiHideo KigoshiGraduate School of Pure and Applied Sciences, University of Tsukuba1-1-1 TennodaiTsukuba 305-8571Japan[email protected]Search for other works by this author on:
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CHAPTER 7: Targeted Protein Degradation Chemical Probesp150-181ByC. Galdeano;C. GaldeanoDepartment of Pharmacy, Pharmaceutical Technology and Physical Chemistry, Faculty of Pharmacy and Food Science, and Institute of Biomedicine (IBUB), University of Barcelona08028 BarcelonaSpain[email protected]Search for other works by this author on:X. BarrilX. BarrilDepartment of Pharmacy, Pharmaceutical Technology and Physical Chemistry, Faculty of Pharmacy and Food Science, and Institute of Biomedicine (IBUB), University of Barcelona08028 BarcelonaSpain[email protected]Catalan Institution for Research and Advanced Studies (ICREA), Passeig Lluis Companys 2308010 BarcelonaSpainSearch for other works by this author on:
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CHAPTER 8: Chemical Probes for Kinasesp182-213ByXiaoyun Lu;Xiaoyun LuInternational Cooperative Laboratory of Traditional Chinese Medicine Modernization and Innovative Drug Discovery of the Chinese Ministry of Education (MOE), School of Pharmacy, Jinan University601 Huangpu Avenue WestGuangzhou 510632ChinaSearch for other works by this author on:Jeff B. Smaill;Jeff B. SmaillMWC–JNU International Joint Laboratory, Maurice Wilkins Centre for Molecular Biodiscovery, University of AucklandPrivate Bag 92019Auckland 1142New Zealand[email protected]Search for other works by this author on:Ke DingKe DingInternational Cooperative Laboratory of Traditional Chinese Medicine Modernization and Innovative Drug Discovery of the Chinese Ministry of Education (MOE), School of Pharmacy, Jinan University601 Huangpu Avenue WestGuangzhou 510632ChinaSearch for other works by this author on:
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CHAPTER 9: Chemical Probes to Control RNA Functionp214-246ByLiberty François-Moutal;Liberty François-MoutalDepartment of Pharmacology, College of Medicine, University of ArizonaTucsonAZ 85724USASearch for other works by this author on:Victor Miranda;Victor MirandaDepartment of Pharmacology, College of Medicine, University of ArizonaTucsonAZ 85724USASearch for other works by this author on:Michael Sandino;Michael SandinoDepartment of Pharmacology, College of Medicine, University of ArizonaTucsonAZ 85724USASearch for other works by this author on:May KhannaMay KhannaDepartment of Pharmacology, College of Medicine, University of ArizonaTucsonAZ 85724USASearch for other works by this author on:
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CHAPTER 10: Assays to Characterize the Cellular Pharmacology of a Chemical Probep247-275ByJakub Stefaniak;Jakub StefaniakStructural Genomics Consortium, Nuffield Department of Medicine, University of OxfordOxford OX3 7DQUKTarget Discovery Institute, Nuffield Department of Medicine, University of OxfordOxford OX3 7FZUK[email protected]Search for other works by this author on:Sébastien R. G. Galan;Sébastien R. G. GalanDepartment of Chemistry, Chemistry Research Laboratory, University of OxfordOxford OX1 3TAUKSearch for other works by this author on:Kilian V. M. HuberKilian V. M. HuberStructural Genomics Consortium, Nuffield Department of Medicine, University of OxfordOxford OX3 7DQUKTarget Discovery Institute, Nuffield Department of Medicine, University of OxfordOxford OX3 7FZUK[email protected]Search for other works by this author on:
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CHAPTER 11: Chemical Probes in Cellular Assays for Target Validation and Screening in Neurodegenerationp276-319ByAna M. Silva;Ana M. SilvaAlzheimer's Research UK Oxford Drug Discovery Institute, Nuffield Department of Medicine, University of OxfordOld Road Campus, Roosevelt DriveOxford OX3 7FZUKTarget Discovery Institute, Nuffield Department of Medicine, University of OxfordOld Road Campus, Roosevelt DriveOxford OX3 7FZUK[email protected]Present address: Medical Research Council Centre for Molecular Bacteriology and Infection, Department of Infectious Disease, Imperial College LondonArmstrong RoadLondon SW7 2AZUKSearch for other works by this author on:Anna Cederbalk;Anna CederbalkAlzheimer's Research UK Oxford Drug Discovery Institute, Nuffield Department of Medicine, University of OxfordOld Road Campus, Roosevelt DriveOxford OX3 7FZUKPresent address: Medical Research Council Centre for Molecular Bacteriology and Infection, Department of Infectious Disease, Imperial College LondonArmstrong RoadLondon SW7 2AZUKSearch for other works by this author on:Daniel Ebner;Daniel EbnerTarget Discovery Institute, Nuffield Department of Medicine, University of OxfordOld Road Campus, Roosevelt DriveOxford OX3 7FZUK[email protected]Present address: Medical Research Council Centre for Molecular Bacteriology and Infection, Department of Infectious Disease, Imperial College LondonArmstrong RoadLondon SW7 2AZUKSearch for other works by this author on:Elena Di DanielElena Di DanielAlzheimer's Research UK Oxford Drug Discovery Institute, Nuffield Department of Medicine, University of OxfordOld Road Campus, Roosevelt DriveOxford OX3 7FZUKPresent address: Medical Research Council Centre for Molecular Bacteriology and Infection, Department of Infectious Disease, Imperial College LondonArmstrong RoadLondon SW7 2AZUKSearch for other works by this author on:
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