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Book cover for The Discovery and Utility of Chemical Probes in Target Discovery
Chemical Biology
The Discovery and Utility of Chemical Probes in Target DiscoveryCheck Access
Edited by
Paul Brennan
Paul Brennan
University of Oxford, UK
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Saleta Vazquez Rodriguez
Saleta Vazquez Rodriguez
University of Oxford, UK
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DOI:
https://doi.org/10.1039/9781839160745
Hardback ISBN:
978-1-78801-589-9
PDF ISBN:
978-1-83916-074-5
EPUB ISBN:
978-1-83916-084-4
Special Collection: 2020 ebook collection
No. of Pages:
326
Published online:
17 Nov 2020
Published in print:
26 Nov 2020
Book Chapter

CHAPTER 11: Chemical Probes in Cellular Assays for Target Validation and Screening in Neurodegeneration Check Access

By
Ana M. Silva
Ana M. Silva
Alzheimer's Research UK Oxford Drug Discovery Institute, Nuffield Department of Medicine, University of Oxford
Old Road Campus, Roosevelt Drive
Oxford OX3 7FZ
UK
Target Discovery Institute, Nuffield Department of Medicine, University of Oxford
Old Road Campus, Roosevelt Drive
Oxford OX3 7FZ
UK
[email protected]
Present address: Medical Research Council Centre for Molecular Bacteriology and Infection, Department of Infectious Disease, Imperial College London
Armstrong Road
London SW7 2AZ
UK
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;
Anna Cederbalk
Anna Cederbalk
Alzheimer's Research UK Oxford Drug Discovery Institute, Nuffield Department of Medicine, University of Oxford
Old Road Campus, Roosevelt Drive
Oxford OX3 7FZ
UK
Present address: Medical Research Council Centre for Molecular Bacteriology and Infection, Department of Infectious Disease, Imperial College London
Armstrong Road
London SW7 2AZ
UK
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;
Daniel Ebner
Daniel Ebner
Target Discovery Institute, Nuffield Department of Medicine, University of Oxford
Old Road Campus, Roosevelt Drive
Oxford OX3 7FZ
UK
[email protected]
Present address: Medical Research Council Centre for Molecular Bacteriology and Infection, Department of Infectious Disease, Imperial College London
Armstrong Road
London SW7 2AZ
UK
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;
Elena Di Daniel
Elena Di Daniel
Alzheimer's Research UK Oxford Drug Discovery Institute, Nuffield Department of Medicine, University of Oxford
Old Road Campus, Roosevelt Drive
Oxford OX3 7FZ
UK
Present address: Medical Research Council Centre for Molecular Bacteriology and Infection, Department of Infectious Disease, Imperial College London
Armstrong Road
London SW7 2AZ
UK
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Doi:
https://doi.org/10.1039/9781839160745-00276
Page range:
276 - 319

The mechanisms underlying neurodegenerative diseases remain poorly understood, compromising the development of effective therapies. Chemical probes are useful tools to investigate the biological relevance of potential targets in cell-based disease models. This chapter reviews compounds that have emerged from cellular target-based and phenotypic screenings, focusing on Alzheimer's and Parkinson's diseases. Further, it makes recommendations on the use of good chemical probes that may help improve our understanding of neurodegeneration and serve as leads for therapeutic development.

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