Catalytic Aerobic Oxidations
CHAPTER 5: Aerobic Oxidations Reactions Using Metal-free Homogeneous Systems
Published:14 Jul 2020
Special Collection: 2020 ebook collectionSeries: Catalysis Series
F. Unglaube, E. Mejía, 2020. "Aerobic Oxidations Reactions Using Metal-free Homogeneous Systems", Catalytic Aerobic Oxidations, Esteban Mejía
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This chapter provides an overview and a critical analysis on the most recent advances on the field of homogeneous metal-free oxidation catalysts. Special focus will be put on the accepted and proposed reaction mechanisms, as well as on the possibilities and limitations of these systems. Moreover, we will compare them to the known and well-established metal-based and enzymatic systems, which in turn will be discussed in separate chapters of this book. The modus operandi for the majority of metal-free oxidation systems involves electron-transfer processes from gaseous oxygen to the substrate with the intermediacy semi-stable organic radicals, although closed-shell transition states have also being reported. N-Oxyl catalysts are used here as benchmark to illustrate the specific properties and reactivity that a compound requires to be a good oxidation catalyst. Moreover, hypervalent iodine compounds, bio-mimetic and bio-inspired systems and other systems based on elemental catalysts and radical cations are presented and discussed.