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Bone is a representative hybrid tissue found in the native body and composed of collagen type I and hydroxycarbonated apatite that exhibits highly organised hierarchical structures from the nano- to the macroscale. Bone tissue engineering aims to overcome risks associated with current clinical bone repair strategies by providing alternative graft materials. A successful scaffold should ideally reflect bone, in terms of both composition and structure. Therefore, in this chapter, the defining characteristics of bone and the potential for hybrid scaffold materials, in particular mineralised collagen constructs, are discussed, to review the materials and manufacturing methods for effective biomimicry within bone tissue engineering.

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