Detection Methods in Precision Medicine
Precision medicine is a topical subject that attracts tremendous attention from scientific and medical communities, being set to transform health care in the future. This book will be among the first to cover the detection methods for precision medicine. The first section provides an overview of the biomarkers used for precision medicine, such as proteins, nucleic acids, and metabolites. The coverage then turns to sequencing techniques and their applications, and other bioanalytical techniques, including mass spectrometry for proteome and phosphoproteome analysis, immunological methods and droplet technologies. The final sections include biosensors applied to precision medicine and clinical applications.
This book provides a reference for researchers and students interested and working in the development of bioanalytical techniques for clinical applications. It provides a useful introduction for physicians and medical laboratory technologists to the recent advances in detection methods for precision medicine.
Detection Methods in Precision Medicine, The Royal Society of Chemistry, 2020.
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Table of contents
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CHAPTER 1: Genome-wide Discovery of MicroRNA Biomarkers for Cancer Precision Medicinep1-34ByZhongxu Zhu;Zhongxu ZhuDepartment of Biomedical Sciences, City University of Hong Kong31 To Yuen StreetKowloon TongHong KongChina[email protected]Search for other works by this author on:Guiyuan Han;Guiyuan HanDepartment of Biomedical Sciences, City University of Hong Kong31 To Yuen StreetKowloon TongHong KongChina[email protected]Search for other works by this author on:Hao Huang;Hao HuangDepartment of Biomedical Sciences, City University of Hong Kong31 To Yuen StreetKowloon TongHong KongChina[email protected]Search for other works by this author on:Lingli He;Lingli HeDepartment of Biomedical Sciences, City University of Hong Kong31 To Yuen StreetKowloon TongHong KongChina[email protected]Search for other works by this author on:Yu Chen;Yu ChenDepartment of Biomedical Sciences, City University of Hong Kong31 To Yuen StreetKowloon TongHong KongChina[email protected]Search for other works by this author on:Jia Ke;Jia KeThe Sixth Affiliated Hospital of Sun Yat-Sen UniversityGuangzhouChinaSearch for other works by this author on:Feng Gao;Feng GaoThe Sixth Affiliated Hospital of Sun Yat-Sen UniversityGuangzhouChinaSearch for other works by this author on:Louis Vermeulen;Louis VermeulenAmsterdam UMC, University of Amsterdam, Laboratory for Experimental Oncology and Radiobiology, Center for Experimental and Molecular Medicine, Cancer Center Amsterdam and Amsterdam Gastroenterology and MetabolismMeibergdreef 91105AmsterdamAZNetherlandsSearch for other works by this author on:Xin WangXin WangDepartment of Biomedical Sciences, City University of Hong Kong31 To Yuen StreetKowloon TongHong KongChina[email protected]Shenzhen Research Institute, City University of Hong KongShenzhenChinaSearch for other works by this author on:
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CHAPTER 2: Extracellular Vesicles in Precision Medicinep35-57ByO. Ruhen;O. RuhenThe Institute of Cancer Research15 Cotswold RoadSuttonSurreyUKSearch for other works by this author on:K. MeehanK. MeehanDepartment of Otorhinolaryngology, Head and Neck Surgery, Chinese University of Hong Kong, Lui Che Woo Clinical Sciences Building, Prince of Wales HospitalShatinN.T. Hong KongChina[email protected]Search for other works by this author on:
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CHAPTER 3: Proteomics in Precision Medicinep58-72ByJiangnan Zheng;Jiangnan ZhengDepartment of Chemistry, Southern University of Science and TechnologyShenzhen 518055China[email protected][email protected]Search for other works by this author on:An He;An HeDepartment of Chemistry, Southern University of Science and TechnologyShenzhen 518055China[email protected][email protected]Search for other works by this author on:Yiheng Mao;Yiheng MaoDepartment of Chemistry, Southern University of Science and TechnologyShenzhen 518055China[email protected][email protected]Search for other works by this author on:Lijun Yang;Lijun YangDepartment of Chemistry, Southern University of Science and TechnologyShenzhen 518055China[email protected][email protected]Search for other works by this author on:Chris Soon Heng Tan;Chris Soon Heng TanDepartment of Chemistry, Southern University of Science and TechnologyShenzhen 518055China[email protected][email protected]Search for other works by this author on:Ruijun TianRuijun TianDepartment of Chemistry, Southern University of Science and TechnologyShenzhen 518055China[email protected][email protected]Search for other works by this author on:
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CHAPTER 4: Computational Prediction of Tumor Neoantigen for Precision Oncologyp73-87ByShaojun TangShaojun TangDepartment of Oncology, Georgetown University Medical Center, Georgetown UniversityWashington D.C.USA[email protected]Department of Biomedical Sciences, City University of Hong KongKowloonHong KongChinaSearch for other works by this author on:
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CHAPTER 5: Big Data and Its Emerging Role in Precision Medicine and Therapeutic Responsep88-116ByNusrat J. Epsi;Nusrat J. EpsiDepartment of Health Informatics, Rutgers School of Health Professions, Rutgers Biomedical and Health SciencesNewarkNJ 07107USASearch for other works by this author on:Sukanya Panja;Sukanya PanjaDepartment of Health Informatics, Rutgers School of Health Professions, Rutgers Biomedical and Health SciencesNewarkNJ 07107USASearch for other works by this author on:Antonina MitrofanovaAntonina MitrofanovaDepartment of Health Informatics, Rutgers School of Health Professions, Rutgers Biomedical and Health SciencesNewarkNJ 07107USARutgers Cancer Institute of New Jersey, Rutgers, The State University of New JerseyNew BrunswickNJ 08901USA[email protected]Search for other works by this author on:
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CHAPTER 6: Detection of Disease-associated Mutations and Biomarkers Using Next-generation Sequencingp117-136ByJian Yan;Jian YanDepartment of Biomedical Sciences, City University of Hong KongKowloonHong KongChina[email protected]Search for other works by this author on:Xi WangXi WangGerman Cancer Research CenterHeidelbergGermanySearch for other works by this author on:
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CHAPTER 7: Nanopore Sequencing and Detection of Tumor Mutationsp137-152ByYu Chen;Yu ChenDepartment of Biomedical Sciences, City University of Hong KongKowloonHong KongChina[email protected]Search for other works by this author on:Xiaoyu Zhou;Xiaoyu ZhouDepartment of Biomedical Sciences, City University of Hong KongKowloonHong KongChina[email protected]Search for other works by this author on:Mengsu YangMengsu YangDepartment of Biomedical Sciences, City University of Hong KongKowloonHong KongChina[email protected]Search for other works by this author on:
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CHAPTER 8: Analytical Challenges of Next-generation Sequencing in Precision Medicinep153-168ByMatthew R. LiebersMatthew R. LiebersSearch for other works by this author on:
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CHAPTER 9: Single-cell Sequencing of Circulating Tumor Cells: Recent Technical Advances, Challenges and Applicationsp169-190ByYing Ni;Ying NiDepartment of Biomedical Sciences, City University of Hong KongKowloonHong KongChina[email protected]Search for other works by this author on:Yuzhu Cui;Yuzhu CuiDepartment of Biomedical Sciences, City University of Hong KongKowloonHong KongChina[email protected]Search for other works by this author on:Heng Zou;Heng ZouCellomics (Shenzhen) LimitedTower A, Haikexing Industrial ParkPing ShanShenzhenChina[email protected]Search for other works by this author on:Tao Xu;Tao XuCellomics (Shenzhen) LimitedTower A, Haikexing Industrial ParkPing ShanShenzhenChina[email protected]Search for other works by this author on:Mengsu YangMengsu YangDepartment of Biomedical Sciences, City University of Hong KongKowloonHong KongChina[email protected]Search for other works by this author on:
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CHAPTER 10: Applications for Mass Spectrometry-based Proteomics and Phosphoproteomics in Precision Medicinep191-222BySara L. Banerjee;Sara L. BanerjeeCentre de recherche du Centre Hospitalier Universitaire (CHU) de Québec-Université Laval, Axe OncologieQuébecQCCanada[email protected]Centre de recherche sur le cancer de l'Université LavalQuébecQCCanadaPROTEO-Quebec Network for Research on Protein Function, Engineering, and ApplicationsQuébecCanadaSearch for other works by this author on:Ugo Dionne;Ugo DionneCentre de recherche du Centre Hospitalier Universitaire (CHU) de Québec-Université Laval, Axe OncologieQuébecQCCanada[email protected]Centre de recherche sur le cancer de l'Université LavalQuébecQCCanadaPROTEO-Quebec Network for Research on Protein Function, Engineering, and ApplicationsQuébecCanadaSearch for other works by this author on:Ana I. Osornio-Hernandez;Ana I. Osornio-HernandezCentre de recherche du Centre Hospitalier Universitaire (CHU) de Québec-Université Laval, Axe OncologieQuébecQCCanada[email protected]Centre de recherche sur le cancer de l'Université LavalQuébecQCCanadaPROTEO-Quebec Network for Research on Protein Function, Engineering, and ApplicationsQuébecCanadaSearch for other works by this author on:Nicolas BissonNicolas BissonCentre de recherche du Centre Hospitalier Universitaire (CHU) de Québec-Université Laval, Axe OncologieQuébecQCCanada[email protected]Centre de recherche sur le cancer de l'Université LavalQuébecQCCanadaPROTEO-Quebec Network for Research on Protein Function, Engineering, and ApplicationsQuébecCanadaDepartment of Molecular Biology, Medical Biochemistry and Pathology, Université LavalQuébecQCCanadaSearch for other works by this author on:
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CHAPTER 11: Immunological Detection Methods for Biomarkersp223-252ByKing Hoo Lim;King Hoo LimDepartment of Biomedical Sciences, City University of Hong KongKowloon TongHong KongPeople's Republic of China[email protected]Search for other works by this author on:Eunice Dotse;Eunice DotseDepartment of Biomedical Sciences, City University of Hong KongKowloon TongHong KongPeople's Republic of China[email protected]Search for other works by this author on:Kwan T. ChowKwan T. ChowDepartment of Biomedical Sciences, City University of Hong KongKowloon TongHong KongPeople's Republic of China[email protected]Search for other works by this author on:
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CHAPTER 12: Droplet Microfluidics for Precision Medicinep253-278BySze Nga Lai;Sze Nga LaiDepartment of Chemistry, The Chinese University of Hong KongShatinHong Kong SARChina[email protected]Search for other works by this author on:Xiaofei Ouyang;Xiaofei OuyangDepartment of Chemistry, The Chinese University of Hong KongShatinHong Kong SARChina[email protected]Search for other works by this author on:Bo ZhengBo ZhengDepartment of Chemistry, The Chinese University of Hong KongShatinHong Kong SARChina[email protected]Search for other works by this author on:
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CHAPTER 13: POCT for Nucleic Acids by Using Colorimetric Nanoprobesp279-302ByShiyao Wang;Shiyao WangDepartment of Biomedical Engineering, The Hong Kong Polytechnic UniversityHung HomKowloonHong Kong[email protected]Search for other works by this author on:Thomas M. H. LeeThomas M. H. LeeDepartment of Biomedical Engineering, The Hong Kong Polytechnic UniversityHung HomKowloonHong Kong[email protected]Search for other works by this author on:
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CHAPTER 14: Cell and Immune Therapyp303-344ByKevin Wijanarko;Kevin WijanarkoDepartment of Biomedical Sciences, City University of Hong KongKowloon TongHong KongPeople's Republic of China[email protected]Search for other works by this author on:Meijun Wang;Meijun WangDepartment of Biomedical Sciences, City University of Hong KongKowloon TongHong KongPeople's Republic of China[email protected]Search for other works by this author on:Kwan T. ChowKwan T. ChowDepartment of Biomedical Sciences, City University of Hong KongKowloon TongHong KongPeople's Republic of China[email protected]Search for other works by this author on:
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CHAPTER 15: Precision Oncologyp345-362ByMatthew R. LiebersMatthew R. LiebersSearch for other works by this author on:
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