Detection Methods in Precision Medicine
CHAPTER 14: Cell and Immune Therapy
Published:10 Dec 2020
Special Collection: 2020 ebook collectionSeries: Detection Science
Kevin Wijanarko, Meijun Wang, Kwan T. Chow, 2020. "Cell and Immune Therapy", Detection Methods in Precision Medicine, Mengsu (Michael) Yang, Michael Thompson
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The importance of the immune system in the pathogenesis of multiple diseases is a field of intense study. Efforts to modulate immune responses via cytokines in cancer therapy has been tried since the 1980s, but only recently have immunotherapies played a more substantial role in oncology. Within the last decade, the adoption of checkpoint inhibitors in clinical use has become one of the greatest success stories from the field. However, many other therapeutic avenues are also being actively researched, including CAR-T cell immunotherapies as well as dendritic cell vaccines. An often-reported weakness with immunotherapies is their efficacy in only a small proportion of individuals as well as severe side effects. The increasing research on precision medicine and combination therapies allow for patient-targeted immunotherapeutic regimens to be developed to minimize adverse reactions and increase their efficacy. As next-generation sequencing also becomes increasingly more accessible and affordable, the potential of developing patient-tailored personalised therapies becomes more promising. With the increasing integration of immunotherapies into mainstream oncology, increased focus on patient targeting based on precision medicine will hopefully push immunotherapies to become well-tolerated and effective agents in the coming decades.