Advanced diffusion encoding strategies open new windows of exploration into microstructure in vivo. Their success in research and clinical applications relies on imaging methods able to sample this multidimensional parameter space efficiently to provide high quality data. Furthermore, creative strategies to encode novel contrasts, such as combined relaxation–diffusion correlation weightings and novel diffusion preparations can in turn inspire new analysis possibilities. This chapter introduces the most commonly used single-shot Cartesian echo planar imaging technique, discusses acceleration strategies and introduces concepts for increased flexibility.