Processing Metabolomics and Proteomics Data with Open Software: A Practical Guide
CHAPTER 11: Metabolite Annotation With CEU Mass Mediator
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Published:16 Mar 2020
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Special Collection: 2020 ebook collection
Alberto Gil-de-la-Fuente, Joanna Godzien, Abraham Otero, Coral Barbas, 2020. "Metabolite Annotation With CEU Mass Mediator", Processing Metabolomics and Proteomics Data with Open Software: A Practical Guide, Robert Winkler
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Metabolite identification is one of the most challenging steps in metabolomics and is often the main bottleneck in the entire workflow.1 A low identification rate hinders biological interpretation of the experiment due to many pieces of the puzzle being missing. A significant misidentification rate could lead to inconsistent analysis of the results and even wrong biological interpretations.2 Achieving a high percentage of correct metabolite identifications is fundamental for subsequent biological interpretation.
There are several classifications of confidence levels for the identification of metabolites;3 the most popular is that proposed by the Metabolomics Society. It includes five different...