Soft Matter for Biomedical Applications
Dynamic soft materials that have the ability to expand and contract, change stiffness, self-heal or dissolve in response to environmental changes, are of great interest in applications ranging from biosensing and drug delivery to soft robotics and tissue engineering. This book covers the state-of-the-art and current trends in the very active and exciting field of bioinspired soft matter, its fundamentals and comprehension from the structural-property point of view, as well as materials and cutting-edge technologies that enable their design, fabrication, advanced characterization and underpin their biomedical applications.
The book contents are supported by illustrated examples, schemes, and figures, offering a comprehensive and thorough overview of key aspects of soft matter. The book will provide a trusted resource for undergraduate and graduate students and will extensively benefit researchers and professionals working across the fields of chemistry, biochemistry, polymer chemistry, materials science and engineering, nanosciences, nanotechnologies, nanomedicine, biomedical engineering and medical sciences.
Soft Matter for Biomedical Applications, The Royal Society of Chemistry, 2021.
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Table of contents
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Chapter 1: The Mutable Collagenous Tissue of Echinoderms: From Biology to Biomedical Applicationsp1-33ByI. C. Wilkie;I. C. WilkieUniversity of Glasgow, Institute of Biodiversity, Animal Health and Comparative MedicineGlasgow G12 8QQUK[email protected]Search for other works by this author on:M. Sugni;M. SugniUniversity of Milan, Department of Environmental Science and PolicyMilan 20133ItalySearch for other works by this author on:H. S. Gupta;H. S. GuptaQueen Mary University of London, School of Engineering and Materials ScienceLondon E1 4NSUKSearch for other works by this author on:M. D. Candia Carnevali;M. D. Candia CarnevaliUniversity of Milan, Department of Environmental Science and PolicyMilan 20133ItalySearch for other works by this author on:M. R. ElphickM. R. ElphickQueen Mary University of London, School of Biological and Chemical SciencesLondon E1 4NSUKSearch for other works by this author on:
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Chapter 2: Synchrotron X-ray Imaging Combined with Multiscale Modeling Applied to Biological Soft Tissuesp34-60ByH. S. Gupta;H. S. GuptaInstitute of Bioengineering and School of Engineering and Material Science, Queen Mary University of LondonLondonE1 4NSUK[email protected]Search for other works by this author on:E. Barbieri;E. BarbieriCentre for Mathematical Science and Advanced Technology, Research Institute for Value-Added Information Generation, Japan Agency for Marine-Earth Science and Technology, 3173-25, Showa-machi, Kanazawa-kuYokohama-cityJapan[email protected]Search for other works by this author on:S. R. Inamdar;S. R. InamdarInstitute of Bioengineering and School of Engineering and Material Science, Queen Mary University of LondonLondonE1 4NSUK[email protected]Search for other works by this author on:J. MoJ. MoDepartment of Mechanical Engineering Sciences, University of SurreyGuildfordGU2 7XHUKSearch for other works by this author on:
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Chapter 3: Biomimetic and Collagen-based Biomaterials for Biomedical Applicationsp61-87ByL. CipollaL. CipollaDept. of Biosciences and Biotechnology, University of Milano - BicoccaPiazza della Scienza 220126 MilanItaly[email protected]Search for other works by this author on:
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Chapter 4: Silk Fibroin-based Soft Biomaterial/Scaffolds for Tissue Engineering Strategiesp88-111ByY. Yang;Y. YangDepartment of Industrial Engineering and BIOtech Research Center, University of TrentoTrentoItaly[email protected]European Institute of Excellence on Tissue Engineering and Regenerative Medicine UnitTrentoItalySearch for other works by this author on:E. Spessot;E. SpessotDepartment of Industrial Engineering and BIOtech Research Center, University of TrentoTrentoItaly[email protected]European Institute of Excellence on Tissue Engineering and Regenerative Medicine UnitTrentoItalySearch for other works by this author on:A. MottaA. MottaDepartment of Industrial Engineering and BIOtech Research Center, University of TrentoTrentoItaly[email protected]European Institute of Excellence on Tissue Engineering and Regenerative Medicine UnitTrentoItalySearch for other works by this author on:
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Chapter 5: Protein Aggregation Suppression and Folding Promotion by Synthetic Moleculesp112-133ByT. MuraokaT. MuraokaTokyo University of Agriculture and Technology, Department of Applied Chemistry, Graduate School of Engineering2-24-16 Naka-cho, Koganei184-8588TokyoJapan[email protected]Search for other works by this author on:
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Chapter 6: Levan Polysaccharide for Biomedical Applicationsp134-154ByO. Kırtel;O. KırtelIBSB- Industrial Biotechnology and Systems Biology Research Group, Marmara University, Department of BioengineeringIstanbul34722Turkey[email protected]Search for other works by this author on:E. T. ÖnerE. T. ÖnerIBSB- Industrial Biotechnology and Systems Biology Research Group, Marmara University, Department of BioengineeringIstanbul34722Turkey[email protected]Search for other works by this author on:
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Chapter 7: Alginate Particulate Gels for Oral Drug Deliveryp155-179ByA. SosnikA. SosnikLaboratory of Pharmaceutical Nanomaterials Science, Department of Materials Science and Engineering, Technion-Israel Institute of TechnologyTechnion City, HaifaIsrael[email protected][email protected]Search for other works by this author on:
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Chapter 8: Extending the Functionality of Marine-origin Polysaccharides Through Chemical Modification for Biomedical Applicationsp180-204ByJ. M. M. Rodrigues;J. M. M. RodriguesDepartment of Chemistry, CICECO - Aveiro Institute of Materials, University of Aveiro3810-193 AveiroPortugal[email protected]Search for other works by this author on:E. J. Castanheira;E. J. CastanheiraDepartment of Chemistry, CICECO - Aveiro Institute of Materials, University of Aveiro3810-193 AveiroPortugal[email protected]Search for other works by this author on:D. C. S. Costa;D. C. S. CostaDepartment of Chemistry, CICECO - Aveiro Institute of Materials, University of Aveiro3810-193 AveiroPortugal[email protected]Search for other works by this author on:D. H. A. Rocha;D. H. A. RochaDepartment of Chemistry, CICECO - Aveiro Institute of Materials, University of Aveiro3810-193 AveiroPortugal[email protected]Search for other works by this author on:J. Borges;J. BorgesDepartment of Chemistry, CICECO - Aveiro Institute of Materials, University of Aveiro3810-193 AveiroPortugal[email protected]Search for other works by this author on:J. F. ManoJ. F. ManoDepartment of Chemistry, CICECO - Aveiro Institute of Materials, University of Aveiro3810-193 AveiroPortugal[email protected]Search for other works by this author on:
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Chapter 9: Elastin-like Recombinamers (ELRs) for Biomedical Applicationsp205-235ByI. González de Torre;I. González de TorreBIOFORGE (Group for Advanced Materials and Nanobiotechnology), University of Valladolid, CIBER-BBN47011 ValladolidSpain[email protected]Search for other works by this author on:M. González-Pérez;M. González-PérezBIOFORGE (Group for Advanced Materials and Nanobiotechnology), University of Valladolid, CIBER-BBN47011 ValladolidSpain[email protected]Search for other works by this author on:M. Alonso;M. AlonsoBIOFORGE (Group for Advanced Materials and Nanobiotechnology), University of Valladolid, CIBER-BBN47011 ValladolidSpain[email protected]Search for other works by this author on:J. C. Rodríguez-CabelloJ. C. Rodríguez-CabelloBIOFORGE (Group for Advanced Materials and Nanobiotechnology), University of Valladolid, CIBER-BBN47011 ValladolidSpain[email protected]Search for other works by this author on:
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Chapter 10: Minimalistic Peptide Self-assembly into Supramolecular Biomaterialsp236-263ByM. C. Cringoli;M. C. CringoliUniversity of Trieste, Department of Chemical and Pharmaceutical SciencesVia L. Giorgieri 1Trieste34127Italy[email protected]INSTM Trieste Research UnitVia L. Giorgieri 1Trieste34127ItalySearch for other works by this author on:P. Fornasiero;P. FornasieroUniversity of Trieste, Department of Chemical and Pharmaceutical SciencesVia L. Giorgieri 1Trieste34127Italy[email protected]INSTM Trieste Research UnitVia L. Giorgieri 1Trieste34127ItalyICCOM-CNR Trieste Research UnitVia L. Giorgieri 1Trieste34127ItalySearch for other works by this author on:S. MarchesanS. MarchesanUniversity of Trieste, Department of Chemical and Pharmaceutical SciencesVia L. Giorgieri 1Trieste34127Italy[email protected]INSTM Trieste Research UnitVia L. Giorgieri 1Trieste34127ItalySearch for other works by this author on:
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Chapter 11: Recent Advances in the Design of Surface-initiated Polymer Brushes for Biomedical Applicationsp264-300ByF. Qu;F. QuInstitute of Bioengineering, Queen Mary University of LondonMile End RoadLondon E1 4NSUnited Kingdom[email protected]School of Engineering and Materials Science, Queen Mary University of LondonMile End RoadLondon E1 4NSUnited KingdomDepartment of Applied Chemistry, School of Natural and Applied Sciences, Northwestern Polytechnical UniversityXi'an 710072PR ChinaSearch for other works by this author on:A. M. Raynold;A. M. RaynoldInstitute of Bioengineering, Queen Mary University of LondonMile End RoadLondon E1 4NSUnited Kingdom[email protected]School of Engineering and Materials Science, Queen Mary University of LondonMile End RoadLondon E1 4NSUnited KingdomSearch for other works by this author on:J. E. GautrotJ. E. GautrotInstitute of Bioengineering, Queen Mary University of LondonMile End RoadLondon E1 4NSUnited Kingdom[email protected]School of Engineering and Materials Science, Queen Mary University of LondonMile End RoadLondon E1 4NSUnited KingdomSearch for other works by this author on:
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Chapter 12: Bioinspired and Bioinstructive Surfaces to Control Mesenchymal Stem Cellsp301-325ByK. Witte;K. WitteUniversity of Strathclyde, Strathclyde Institute of Pharmacy and Biomedical SciencesCathedral StreetGlasgowG4 0REUnited KingdomSearch for other works by this author on:J. Luo;J. LuoUniversity of Glasgow, Centre for the Cellular MicroenvironmentRankine Building, Oakfield AvenueGlasgowG12 8LTUnited Kingdom[email protected]Search for other works by this author on:M. Walker;M. WalkerUniversity of Glasgow, Centre for the Cellular MicroenvironmentRankine Building, Oakfield AvenueGlasgowG12 8LTUnited Kingdom[email protected]Search for other works by this author on:M. Cantini;M. CantiniUniversity of Glasgow, Centre for the Cellular MicroenvironmentRankine Building, Oakfield AvenueGlasgowG12 8LTUnited Kingdom[email protected]Search for other works by this author on:F. P. Seib;F. P. SeibUniversity of Strathclyde, Strathclyde Institute of Pharmacy and Biomedical SciencesCathedral StreetGlasgowG4 0REUnited KingdomSearch for other works by this author on:M. Salmeron-SanchezM. Salmeron-SanchezUniversity of Glasgow, Centre for the Cellular MicroenvironmentRankine Building, Oakfield AvenueGlasgowG12 8LTUnited Kingdom[email protected]Search for other works by this author on:
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Chapter 13: Biomimetic Surface Modifications of Biomaterials Using a Layer-by-layer Techniquep326-362ByR. Anouz;R. AnouzBiomedical Materials Department, Institute of Pharmacy, Martin Luther University Halle Wittenberg06120 Halle(Saale)Germany[email protected]Search for other works by this author on:T. GrothT. GrothBiomedical Materials Department, Institute of Pharmacy, Martin Luther University Halle Wittenberg06120 Halle(Saale)Germany[email protected]Interdisciplinary Center of Materials Research, Martin Luther University Halle WittenbergHeinrich-Damerow Strasse 406120 Halle(Saale)GermanySearch for other works by this author on:
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Chapter 14: Smart Porous Silica–Polymer Nanomaterials for Theranosticsp363-391ByJ. L. M. Gonçalves;J. L. M. GonçalvesCentro de Química Estrutural and Department of Chemical Engineering, Instituto Superior Técnico, Universidade de Lisboa1049-001 LisboaPortugal[email protected][email protected]Search for other works by this author on:C. Baleizão;C. BaleizãoCentro de Química Estrutural and Department of Chemical Engineering, Instituto Superior Técnico, Universidade de Lisboa1049-001 LisboaPortugal[email protected][email protected]Search for other works by this author on:J. P. S. FarinhaJ. P. S. FarinhaCentro de Química Estrutural and Department of Chemical Engineering, Instituto Superior Técnico, Universidade de Lisboa1049-001 LisboaPortugal[email protected][email protected]Search for other works by this author on:
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Chapter 15: Liposomes for Biomedical Applicationsp392-404ByE. Arab-TehranyE. Arab-TehranySearch for other works by this author on:
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Chapter 16: Cyclodextrin-based Drug Delivery Systems Manufactured by Emergent Technologies: 3D-printing, Electrospinning, Microneedles, Microfluidics and MOFsp405-424ByM. A. Grimaudo;M. A. GrimaudoDepartamento de Farmacología, Farmacia y Tecnología Farmacéutica, I + D Farma (GI-1645), Facultad de Farmacia and Health Research Institute of Santiago de Compostela (IDIS), Universidade de Santiago de Compostela15782-Santiago de CompostelaSpain[email protected]Search for other works by this author on:A. Concheiro;A. ConcheiroDepartamento de Farmacología, Farmacia y Tecnología Farmacéutica, I + D Farma (GI-1645), Facultad de Farmacia and Health Research Institute of Santiago de Compostela (IDIS), Universidade de Santiago de Compostela15782-Santiago de CompostelaSpain[email protected]Search for other works by this author on:C. Alvarez-LorenzoC. Alvarez-LorenzoDepartamento de Farmacología, Farmacia y Tecnología Farmacéutica, I + D Farma (GI-1645), Facultad de Farmacia and Health Research Institute of Santiago de Compostela (IDIS), Universidade de Santiago de Compostela15782-Santiago de CompostelaSpain[email protected]Search for other works by this author on:
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Chapter 17: Soft Fibrillar Biomaterials by Fibre Spinning Routesp425-443ByD. Torres Ulloa;D. Torres UlloaDepartment of Materials, School of Natural Sciences, The University of ManchesterManchesterM13 9PLUK[email protected]Search for other works by this author on:J. J. BlakerJ. J. BlakerDepartment of Materials, School of Natural Sciences, The University of ManchesterManchesterM13 9PLUK[email protected]Department of Biomaterials, Institute of Clinical Dentistry, University of OsloOslo317NorwaySearch for other works by this author on:
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Chapter 18: Shaping Soft Structures Using Bottom-up Layer-by-layer Assembly Technology for Biomedical Applicationsp444-473ByJ. Borges;J. BorgesCICECO – Aveiro Institute of Materials, Department of Chemistry, University of Aveiro, Campus Universitário de Santiago3810-193 AveiroPortugal[email protected]Search for other works by this author on:C. F. V. Sousa;C. F. V. SousaCICECO – Aveiro Institute of Materials, Department of Chemistry, University of Aveiro, Campus Universitário de Santiago3810-193 AveiroPortugal[email protected]Search for other works by this author on:I. M. Bjørge;I. M. BjørgeCICECO – Aveiro Institute of Materials, Department of Chemistry, University of Aveiro, Campus Universitário de Santiago3810-193 AveiroPortugal[email protected]Search for other works by this author on:S. Nadine;S. NadineCICECO – Aveiro Institute of Materials, Department of Chemistry, University of Aveiro, Campus Universitário de Santiago3810-193 AveiroPortugal[email protected]Search for other works by this author on:C. R. Correia;C. R. CorreiaCICECO – Aveiro Institute of Materials, Department of Chemistry, University of Aveiro, Campus Universitário de Santiago3810-193 AveiroPortugal[email protected]Search for other works by this author on:S. G. Patrício;S. G. PatrícioCICECO – Aveiro Institute of Materials, Department of Chemistry, University of Aveiro, Campus Universitário de Santiago3810-193 AveiroPortugal[email protected]Search for other works by this author on:J. F. ManoJ. F. ManoCICECO – Aveiro Institute of Materials, Department of Chemistry, University of Aveiro, Campus Universitário de Santiago3810-193 AveiroPortugal[email protected]Search for other works by this author on:
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Chapter 19: Nanobiomaterials for Smart Deliveryp475-498ByJ. A. Duran-Mota;J. A. Duran-MotaDepartment of Bioengineering, Institut Químic de SarriàBarcelonaSpainSearch for other works by this author on:B. D. AlmquistB. D. AlmquistSearch for other works by this author on:
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Chapter 20: Liposomes in Targeted Drug Deliveryp499-517ByW. HeW. HeDepartment of Pharmaceutics, School of Pharmacy, China Pharmaceutical UniversityNanjing 211198PR China[email protected]Search for other works by this author on:
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Chapter 21: Polysaccharide-based Hydrogels for the Controlled Delivery of Therapeutic Biomacromoleculesp518-541ByM. I. Rial-Hermida;M. I. Rial-HermidaDepartment of Chemistry, CICECO - Aveiro Institute of Materials, University of Aveiro3810-193 AveiroPortugal[email protected][email protected]Search for other works by this author on:A. Rey-Rico;A. Rey-RicoCell Therapy and Regenerative Medicine Unit, Centro de Investigacións Científicas Avanzadas (CICA), Universidade da CoruñaA CoruñaSpainSearch for other works by this author on:N. Carballo-Pedrares;N. Carballo-PedraresCell Therapy and Regenerative Medicine Unit, Centro de Investigacións Científicas Avanzadas (CICA), Universidade da CoruñaA CoruñaSpainSearch for other works by this author on:J. F. ManoJ. F. ManoDepartment of Chemistry, CICECO - Aveiro Institute of Materials, University of Aveiro3810-193 AveiroPortugal[email protected][email protected]Search for other works by this author on:
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Chapter 22: Stimuli-responsive Drug Delivery Hydrogelsp542-565ByM. A. Nazeer;M. A. NazeerKoç University, Chemical and Biological Engineering DepartmentSariyer 34450IstanbulTurkey[email protected]Koç University, Research Center for Translational MedicineSariyer 34450IstanbulTurkeySearch for other works by this author on:S. R. Batool;S. R. BatoolKoç University, Biomedical Sciences and Engineering DepartmentSariyer 34450IstanbulTurkeySearch for other works by this author on:S. KizilelS. KizilelKoç University, Chemical and Biological Engineering DepartmentSariyer 34450IstanbulTurkey[email protected]Koç University, Research Center for Translational MedicineSariyer 34450IstanbulTurkeyKoç University, Biomedical Sciences and Engineering DepartmentSariyer 34450IstanbulTurkeySearch for other works by this author on:
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Chapter 23: Stimuli-responsive Nanocomposite Hydrogels Incorporating Soft Nanoparticles for Biomedical Applicationsp566-593ByP. Lavrador;P. LavradorCICECO – Aveiro Institute of Materials, Department of Chemistry, University of Aveiro, Campus Universitário de SantiagoAveiro3810-193Portugal[email protected][email protected]Search for other works by this author on:J. Borges;J. BorgesCICECO – Aveiro Institute of Materials, Department of Chemistry, University of Aveiro, Campus Universitário de SantiagoAveiro3810-193Portugal[email protected][email protected]Search for other works by this author on:V. M. Gaspar;V. M. GasparCICECO – Aveiro Institute of Materials, Department of Chemistry, University of Aveiro, Campus Universitário de SantiagoAveiro3810-193Portugal[email protected][email protected]Search for other works by this author on:J. F. ManoJ. F. ManoCICECO – Aveiro Institute of Materials, Department of Chemistry, University of Aveiro, Campus Universitário de SantiagoAveiro3810-193Portugal[email protected][email protected]Search for other works by this author on:
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Chapter 24: 3D-printed Soft Hydrogels for Cell Encapsulationp594-625ByP. GentileP. GentileSearch for other works by this author on:
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Chapter 25: Decellularized Matrix Hydrogels for In Vitro Disease Modelingp626-659ByL. P. Ferreira;L. P. FerreiraDepartment of Chemistry, CICECO – Aveiro Institute of Materials, University of Aveiro, Campus Universitário de Santiago3810-193AveiroPortugal[email protected][email protected]Search for other works by this author on:M. V. Monteiro;M. V. MonteiroDepartment of Chemistry, CICECO – Aveiro Institute of Materials, University of Aveiro, Campus Universitário de Santiago3810-193AveiroPortugal[email protected][email protected]Search for other works by this author on:V. M. Gaspar;V. M. GasparDepartment of Chemistry, CICECO – Aveiro Institute of Materials, University of Aveiro, Campus Universitário de Santiago3810-193AveiroPortugal[email protected][email protected]Search for other works by this author on:J. F. ManoJ. F. ManoDepartment of Chemistry, CICECO – Aveiro Institute of Materials, University of Aveiro, Campus Universitário de Santiago3810-193AveiroPortugal[email protected][email protected]Search for other works by this author on:
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Chapter 26: Animal Protein-based Soft Materials for Tissue Engineering Applicationsp660-683ByC. A. Custódio;C. A. CustódioCICECO, Department of Chemistry, University of Aveiro, Campus Universitário de Santiago3810-193 AveiroPortugal[email protected][email protected]Search for other works by this author on:S. C. Santos;S. C. SantosCICECO, Department of Chemistry, University of Aveiro, Campus Universitário de Santiago3810-193 AveiroPortugal[email protected][email protected]Search for other works by this author on:C. F. Monteiro;C. F. MonteiroCICECO, Department of Chemistry, University of Aveiro, Campus Universitário de Santiago3810-193 AveiroPortugal[email protected][email protected]Search for other works by this author on:I. A. Deus;I. A. DeusCICECO, Department of Chemistry, University of Aveiro, Campus Universitário de Santiago3810-193 AveiroPortugal[email protected][email protected]Search for other works by this author on:M. C. Gomes;M. C. GomesCICECO, Department of Chemistry, University of Aveiro, Campus Universitário de Santiago3810-193 AveiroPortugal[email protected][email protected]Search for other works by this author on:J. F. ManoJ. F. ManoCICECO, Department of Chemistry, University of Aveiro, Campus Universitário de Santiago3810-193 AveiroPortugal[email protected][email protected]Search for other works by this author on:
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Chapter 27: Soft Robotics Solutions for Minimally Invasive Surgery: The Need for Stiffness Controllabilityp684-719ByJan Fras;Jan FrasJan Fras is with the Centre for Advanced Robotics @ Queen Mary (ARQ), School of Engineering and Materials Science, Queen Mary University of LondonLondon E1 4NSUKSearch for other works by this author on:Alberto Arezzo;Alberto ArezzoAlberto Arezzo is with Department of Surgical Sciences, University of Turinc.so Dogliotti 1410126 TurinItalySearch for other works by this author on:Ali Shiva;Ali ShivaAli Shiva is with Ferdowsi University of Mashhad, Razavi Khorasan ProvinceMashhadIranSearch for other works by this author on:Kaspar AlthoeferKaspar AlthoeferKaspar Althoefer is with the Centre for Advanced Robotics @ Queen Mary (ARQ), School of Engineering and Materials Science, Queen Mary University of LondonLondon E1 4NSUK[email protected]Search for other works by this author on:
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Chapter 28: Cell-based Soft Biomaterialsp720-749ByA. Sofia Silva;A. Sofia SilvaDepartment of Chemistry, CICECO–Aveiro Institute of Materials, University of Aveiro3810-193 AveiroPortugal[email protected][email protected]Search for other works by this author on:Lúcia F. Santos;Lúcia F. SantosDepartment of Chemistry, CICECO–Aveiro Institute of Materials, University of Aveiro3810-193 AveiroPortugal[email protected][email protected]Search for other works by this author on:Mariana B. Oliveira;Mariana B. OliveiraDepartment of Chemistry, CICECO–Aveiro Institute of Materials, University of Aveiro3810-193 AveiroPortugal[email protected][email protected]Search for other works by this author on:João F. ManoJoão F. ManoDepartment of Chemistry, CICECO–Aveiro Institute of Materials, University of Aveiro3810-193 AveiroPortugal[email protected][email protected]Search for other works by this author on:
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