Soft Matter for Biomedical Applications
Chapter 25: Decellularized Matrix Hydrogels for In Vitro Disease Modeling
Published:07 Jun 2021
L. P. Ferreira, M. V. Monteiro, V. M. Gaspar, J. F. Mano, 2021. "Decellularized Matrix Hydrogels for In Vitro Disease Modeling", Soft Matter for Biomedical Applications, Helena S Azevedo, João F Mano, João Borges
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Organ-specific activity is directly dependent on the functional organization of its fundamental building blocks including the resident/infiltrating cell populations and tissue-specific ECM that functions as a crucial element of every tissue and organ.1–3 The notion that the ECM plays a key role in health and disease as evolved in recent decades from the concept of a simplistic supporting structural component toward a highly advanced and complex regulatory platform that is responsible for regulating tissue function and homeostasis.4 In essence, the ECM is a macromolecular mesh mainly comprised of fiber-forming proteins such as collagens and elastic glycoprotein fibers, which...