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Organ-specific activity is directly dependent on the functional organization of its fundamental building blocks including the resident/infiltrating cell populations and tissue-specific ECM that functions as a crucial element of every tissue and organ.1–3  The notion that the ECM plays a key role in health and disease as evolved in recent decades from the concept of a simplistic supporting structural component toward a highly advanced and complex regulatory platform that is responsible for regulating tissue function and homeostasis.4  In essence, the ECM is a macromolecular mesh mainly comprised of fiber-forming proteins such as collagens and elastic glycoprotein fibers, which...

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