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High-throughput screening approaches for the development of novel drugs have led to an increasing number of lipophilic water-insoluble compounds, namely, class 2 or 4 drugs according to the Biopharmaceutics Classification System (BCS).1  The poor physicochemical and biopharmaceutical properties hamper the formulation development of these drug candidates. Among these, poor aqueous solubility is reported to compromise drug absorption across any extravasal route since the concentration gradient between both sides of biological membranes is the main driving force for absorption.2  To overcome these limitations and obtain controllable drug delivery, great efforts are made to develop suitable drug carriers. Among the...

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