High-throughput screening approaches for the discovery of novel drug entities have led to an increasing number of lipophilic water-insoluble compounds, with poor physicochemical and biopharmaceutical properties. In parallel the need of improvements in traditional dosage forms in terms of personalized drug loading, precise control of the release and targeting is prompting the emergence of novel processing technologies. Interestingly, the capability of cyclodextrins (CDs) to interact with an enormous variety of small and large molecules may help addressing the demands of both novel drug candidates and novel processing technologies. In this chapter, recent applications of CDs to the development of 2D/3D-printed architectures, electrospun platforms, microneedles, microfluidics-processed nanoparticles and metal–organic frameworks (MOFs) are revisited. Although the literature is still incipient, analysis of in vitro and in vivo studies highlights the very diverse roles that CDs may play. Thus, far from being out of fashion excipients CDs are increasingly relevant for advanced drug delivery systems and medicated scaffolds.