Soft Matter for Biomedical Applications
Chapter 23: Stimuli-responsive Nanocomposite Hydrogels Incorporating Soft Nanoparticles for Biomedical Applications
Published:07 Jun 2021
P. Lavrador, J. Borges, V. M. Gaspar, J. F. Mano, 2021. "Stimuli-responsive Nanocomposite Hydrogels Incorporating Soft Nanoparticles for Biomedical Applications", Soft Matter for Biomedical Applications, Helena S Azevedo, João F Mano, João Borges
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In their native tissue microenvironments, cells are constantly influenced by a plethora of biochemical and biophysical cues that are dynamically orchestrated by the surrounding extracellular matrix components.1 This supportive hydrogel-like bioarchitecture is inherently perceptive and adaptive in design, being capable of actuating biological responses towards maintaining homoeostasis.2 Following this principle, over the last few decades, researchers have been pursuing the integration of such bioresponsive features within nano-to-macro sized biomaterial platforms(i.e. nanoparticles and hydrogels), in an attempt to mimic the hierarchic features, as well as the adaptive and intelligent behaviour of living tissues.3–5 Engineering stimuli-responsive 3D bioarchitectures...