In their native tissue microenvironments, cells are constantly influenced by a plethora of biochemical and biophysical cues that are dynamically orchestrated by the surrounding extracellular matrix components.¹  This supportive hydrogel-like bioarchitecture is inherently perceptive and adaptive in design, being capable of actuating biological responses towards maintaining homoeostasis.²  Following this principle, over the last few decades, researchers have been pursuing the integration of such bioresponsive features within nano-to-macro sized biomaterial platforms(i.e. nanoparticles and hydrogels), in an attempt to mimic the hierarchic features, as well as the adaptive and intelligent behaviour of living tissues.^3–5  Engineering stimuli-responsive 3D bioarchitectures...