A drug delivery system (DDS) offers a platform to deliver therapeutic substances into the body and enhances its efficacy, potency, and safety by controlling the rate, time, and site of release.¹  Controlled DDS aims to overcome the deficiencies of conventional drug formulations and regulate the bioavailability of therapeutic agents on-demand and in a well-controlled manner.^2,3  During the last few decades, significant progress has been made in pharmaceutical science to treat many clinical disorders, such as cancer, diabetes, and cardiovascular diseases. A promising DDS requires high loading efficiency, cytocompatibility, and on-demand drug release at the target site.⁴  Many...