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A drug delivery system (DDS) offers a platform to deliver therapeutic substances into the body and enhances its efficacy, potency, and safety by controlling the rate, time, and site of release.1  Controlled DDS aims to overcome the deficiencies of conventional drug formulations and regulate the bioavailability of therapeutic agents on-demand and in a well-controlled manner.2,3  During the last few decades, significant progress has been made in pharmaceutical science to treat many clinical disorders, such as cancer, diabetes, and cardiovascular diseases. A promising DDS requires high loading efficiency, cytocompatibility, and on-demand drug release at the target site.4  Many...

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