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Despite the promises of tissue engineering, tissue damage and organ failure remain major health problems with huge socio-economic cost.1  There is significant opportunity for biomaterial solutions towards curative healthcare, ideally these materials would stimulate the body to self-repair, provide an appropriate environment for neo-tissue formation, and degrade. It is possible to spin fibrillar materials and build-up structures and even complex shapes than can re-capitulate aspects of the extracellular matrix (ECM), in terms of morphology, mechanical character, as well as some signalling and instructive elements. This chapter is focused on developments in spun soft fibrillar biomaterials for soft-tissue, the reader...

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