Soft Matter for Biomedical Applications
Chapter 28: Cell-based Soft Biomaterials
Published:07 Jun 2021
A. Sofia Silva, Lúcia F. Santos, Mariana B. Oliveira, João F. Mano, 2021. "Cell-based Soft Biomaterials", Soft Matter for Biomedical Applications, Helena S Azevedo, João F Mano, João Borges
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Tissue engineering (TE) aims at restoring the functionality of damaged tissues and/or organs resulting from trauma, aging or disease.1 The development of structures that mimic the intricate architecture and complexity of native organs and tissues are crucial to guaranty the proper function of the engineered tissues. Traditional TE strategies employ a “top-down” approach, in which cells are seeded onto a scaffold with biocompatible and biodegradable properties.2 Herein, the cells are expected to populate the scaffold and create their own extracellular matrix (ECM) and appropriate microarchitecture. Mechanical stimulation, perfusion or the incorporation of biomolecules like growth factors and signaling...