Soft Matter for Biomedical Applications
Chapter 2: Synchrotron X-ray Imaging Combined with Multiscale Modeling Applied to Biological Soft Tissues
Published:07 Jun 2021
H. S. Gupta, E. Barbieri, S. R. Inamdar, J. Mo, 2021. "Synchrotron X-ray Imaging Combined with Multiscale Modeling Applied to Biological Soft Tissues", Soft Matter for Biomedical Applications, Helena S Azevedo, João F Mano, João Borges
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Soft biological tissues (tendon, cartilage, artery wall, and intervertebral disc) are examples of biomechanically crucial organs which are subjected to a range of loading environments. These range from periodic dynamic loading as in tendons, frictionless sliding as occurs in cartilage at the end of long bones, and cyclic fatigue resistant loading in arteries.1,2 These natural materials provide design templates for their synthetic counterparts to achieve the wide diversity of functional specialisation found in Nature.3,4 To achieve this, the tissues have complex hierarchical structures starting with self-assembly of molecular aggregates at the Angstrom/nanometre scale, through lamellar and fibre bundles...