Soft Matter for Biomedical Applications
Chapter 20: Liposomes in Targeted Drug Delivery
Published:07 Jun 2021
Targeted drug delivery refers to increasing the drug concentration at the diseased site in the body while minimizing unwanted side effects. Liposomes are a commonly used targeted drug delivery system and are a type of enclosed vehicle formed by self-assembling phospholipids and cholesterol in a homocentric pattern. Liposomes were first reported by Bangham and Horne in 1964.1 Owing to their excellent properties in payload capacity, protection of active agent from degradation, stability in vitro and in vivo, improved efficacy, reduced toxicity, alteration of pharmacokinetics and biodistribution, biocompatibility, and scalability, liposomes have been widely employed in biomedicine and drug...