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This chapter describes the recent advances in the development of chiral vanadium complex-catalyzed oxidative-couplings of phenol derivatives. Catalysts containing a vanadium metal and a multidentate ligand prepared from salicylaldehyde derivatives and chiral amino acids provide chemists with a powerful tool for the efficient synthesis of optically active, axially chiral compounds, which can be readily transformed into bioactive compounds and chiral ligands.

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