Virtual Screening of Bio-active Compounds as an Inhibitor of c-FLIP Protein for Cancer Treatment

Cellular FLICE (FADD-like IL-1β-converting enzyme)-inhibitory protein (c-FLIP) is an anti-apoptotic regulatory protein play an important role in cell maintenance and survival to regulate the activation of caspases-8 and -10 proteins in apoptotic signaling pathways. cFLIP mediates death receptors to apoptosis via FAS, TNFR, DR4/DR5, and TNF-related apoptosis-inducing ligand (TRAIL) with the process and activation of procaspase-8 and -10 are over expressed in down process and is the major potential drug targets for cancer therapy. Moreover, abnormal c-FLIP expression has been found in various diseases such as cancer, multiple sclerosis, Alzheimer’s disease, diabetes mellitus, and rheumatoid arthritis. Therefore, c-FLIP-has been identified as potential target for major cancer signaling pathways to inhibit the functions of c-FLIP by targeted therapy. Using computational methods, identified active lead molecules from chemical library databases for the design of potential c-FLIP inhibitors.