Identification of Potential VEGFR2 Inhibitors Employing E-pharmacophore Model, Virtual Screening, Molecular Dynamic Simulation and ADME Analysis

Angiogenesis is an epochal phenomenon which can be targeted to restrain the growth and metastasis of tumor cells. How to target the angiogenesis? Though Angiogenesis is regulated by multiple molecular mediators, VEGF (vascular endothelial growth factor) is a key mediator of angiogenesis. Hence, targeting of VEGF mediated signal transduction pathway is a pivotal way to suppress angiogenesis in tumor cells. Next question is how to target this signal transduction pathway and what are the promising targets to inhibit this process? Before we will address this question, it is essential to understand that VEGF consist of VEGF-A, VEGF-B, VEGF-C, VEGF-D and VEGF-E. Out of all, VEGF-A is a key factor to regulate the angiogenesis phenomenon. However, VEGF-A mediates its biological function through VEGFR-2 (Vascular endothelial growth factor receptor). Hence, VEGFR-2 is the most promising target to suppress angiogenesis in tumor cells.