Synthesis, Antioxidant Activity and Computational Studies 2-Substituted-l-thiaprolines

Supplementation of exogenous antioxidants or boosting endogenous antioxidant defences of the body is a promising way of combating the undesirable effects of reactive oxygen species (ROS) induced oxidative damage. Thiaprolines are considered to be the prodrug of cysteine and they have established to be safe and effective antioxidants. Thiaprolines have been reported to affect the formation and scavenging of reactive oxygen species (ROS) and influence free radical-mediated oxidative damage. Thus the development of new synthesized thiaproline molecules is promising, especially regarding their antioxidant activities. However, reports on development of druggable thiaproline derivatives are limited. In this context, the antioxidant capacities of thiaprolines with different chemical substitutions at its thiazolidine heterocycles have been envisaged. The major focus was to develop thiaproline based antioxidants having better druggability and to understand the molecular mechanism of free radical scavenging effect.