A Novel Nano-enabled Nasal Phytoformulation – a Potential Brain Targeting Strategy for Neurodegenerative Disorders

A major challenge associated with the delivery of drug to the brain is the existence of proficient protective barrier – Blood Brain Barrier (BBB). BBB, a CNS microvasculature that not just protects the brain from foreign substances but also impedes the entry of potential therapeutic agents due to their hydrophilicity or peptide nature. Among the several strategies attempted to overcome this problem and achieve effective treatment for many neurological disorders, properly tailored nanoparticles have a greater potential. Additionally, the administration route also becomes a point of interest in order to attain higher drug delivery to the brain. Intranasal route is one such non-invasive method to bypass the BBB and attain therapeutic concentration in CNS. Moreover, the development of new technologies that would help in delivery of herbal drug to a target site is an interesting approach to consider. Thus, this study was designed with the aim of improving herbal drug delivery to brain via intranasally delivered nanocarriers.