Stability Enhancement and Formulation Development of l-Carnitine Fast Dissolving Pellets Through Pro-drug Approach

l-Carnitine is an imperative compound in human digestion. It is considered as “restrictively fundamental” since few people, including newborn children, can’t combine the compound endogenously at satisfactory dimensions. Since l-Carnitine is exceptionally hygroscopic in nature, it is exceptionally hard to define it in pharmaceutical dose shapes with ideal security and bioavailability. Oral drug administration has been a standout amongst the most advantageous and generally acknowledged courses of conveyance for most remedial operators. The most ordinarily utilized pharmaceutical strong measurement frames today incorporate granules, pellets, tablets and cases, out of which tablets being the most mainstream dose structure, representing 70% of all moral pharmaceutical arrangements delivered. Due to the hygroscopic nature of l-Carnitine, it is difficult to stabilize the drug in various dosage forms. In order to increase the stability and to mask the hygroscopic nature, the current research work was aimed to synthesize l-Carnitine pro-drug and formulated as pellets. The carboxylic group of l-Carnitine has been converted into the corresponding hydrazine via esterification followed by hydrazinolysis approach.