Nanocomposite Hybrid Polymeric Scaffold for Skin Tissue Engineering

Biodegradable polymeric scaffolds have received much attention in tissue engineering as they provide a spatial and temporal environment for cell regeneration. The scaffold can be defined as “any material, natural or artificial that comprises of entire or portion of a living structure or biomedical device which performs, extends or substitutes a natural function”. Biomaterials based scaffolds are projected to interact with living systems and to treat, augment, assess and substitute any function, tissue, and organ of the body. Tissue engineering aims to facilitate the growth and replace the diseased or damaged tissue by using the combination of bioactive molecules, cells, and biomaterials. Many clinical studies were carried out to repair or replace tissue in the human body such as damaged or diseased tissue using autografts, xenografts or allografts (i.e. donor graft tissue). But a major drawback of these treatments is a shortage of donor site or donor rejection of grafts, morbidity, donor site pain, the transmission of disease, the possibility of harmful immune responses and the volume of donor tissue. In the last two decades, rapid progress has been seen in the emerging field of tissue regeneration and tissue engineering.