Analysis of Interaction Between Chlorine Dioxide and Bispyridine-based Irrigating Solution – an Observational Study

Microbial infections are the most common cause of an endodontic disease. To critically reduce bacterial loads, endodontic treatment regimens combine mechanical instrumentation with chemicals, namely irrigation and medication. An optimum agent for endodontic irrigation should have antimicrobial activity, dissolve necrotic tissue, aid in the debridement of the canal system and nontoxic to the periradicular tissues. None of the irrigating solutions used till date possess all the ideal properties. They are used in succession to enhance their individual properties but it is a concern that their interaction could result in reactionary products. This is especially evident when chlorhexidine (CHX) is used in succession with sodium hypochlorite (NaOCl) producing a brown precipitate of parachloroaniline (PCA), which is said to be toxic and carcinogenic and can occlude dentinal tubules. Hence, alternate combinations need to be explored for enhanced properties with no deleterious by-products.