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Conference on Drug Design and Discovery Technologies
Special Publications
Conference on Drug Design and Discovery Technologies
Edited by
Manikanta Murahari
Manikanta Murahari
MS Ramaiah University of Applied Sciences, India
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Lakshmi Sundar
Lakshmi Sundar
MS Ramaiah University of Applied Sciences, India
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Soma Chaki
Soma Chaki
MS Ramaiah University of Applied Sciences, India
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Vasanthanathan Poongavanam
Vasanthanathan Poongavanam
Uppsala University, Sweden
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Pritesh Bhat
Pritesh Bhat
Shrodinger, Bangalore, India
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Usha Y Nayak
Usha Y Nayak
Manipal University, India
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DOI:
https://doi.org/10.1039/9781839160783
Hardback ISBN:
978-1-78801-862-3
PDF ISBN:
978-1-83916-078-3
Special Collection: 2019 ebook collection
No. of Pages:
350
Published online:
19 Nov 2019
Published in print:
20 Nov 2019
Book Chapter

Antimycobacterial Activity of Hexapeptide Related to Apidaecin IA

By
Pandurangan Perumal
Pandurangan Perumal
Faculty of Pharmacy, Asian Institute of Medicine, Science and Technology (AIMST) University
08100 Bedong, Kedah Darul Aman
Malaysia
[email protected]
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;
Prabhu Seenivasan
Prabhu Seenivasan
Department of Bacteriology, National Institute for Research in Tuberculosis
Chetpet, Chennai 600 031
India
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Doi:
https://doi.org/10.1039/9781839160783-00302
Page range:
302 - 318

Background: Apidaecin IA is an animal peptide obtained from honey bee having 18 amino acid presents in the sequence of the peptide. Objective: To design, synthesis, characterization, evaluation of antimycobacterial peptide related to apidaecin IA. Methods; Synthesis by combinatorial chemistry using FMOC chemistry protocol, characterized by mass spectroscopy and sequence analysis using LC-MS-MS and evaluated antifungal, antimicrobial activity by zone of inhibition and minimum inhibitory concentration and antimycobacterial activity by Luciferase Reporter Phage (LRP) assay.

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