Injectable Hydrogels for 3D Bioprinting
Hydrogels represent one of the cornerstones in tissue engineering and regenerative medicine, due to their biocompatibility and physiologically relevant properties. These inherent characteristics mean that they can be widely exploited as bioinks in 3D bioprinting for tissue engineering applications as well as injectable gels for cell therapy and drug delivery purposes. The research in these fields is booming and this book provides the reader with a terrific introduction to the burgeoning field of injectable hydrogel design, bioprinting and tissue engineering.
Edited by three leaders in the field, users of this book will learn about different classes of hydrogels, properties and synthesis strategies to produce bioinks. A section devoted to the key processing and design challenges at the hydrogel/3D bioprinting/tissue interface is also covered. The final section of the book closes with pertinent clinical applications.
Tightly edited, the reader will find this book to be a coherent resource to learn from. It will appeal to those working across biomaterials science, chemical and biomedical engineering, tissue engineering and regenerative medicine.
Injectable Hydrogels for 3D Bioprinting, The Royal Society of Chemistry, 2021.
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Table of contents
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Chapter 1: Overview of Injectable Hydrogels for 3D Bioprinting and Tissue Regenerationp1-20ByGopinathan Janarthanan;Gopinathan JanarthananDepartment of Chemical and Biomolecular Engineering, Seoul National University of Science and TechnologySeoul 01811Republic of Korea[email protected]Convergence Institute of Biomedical Engineering and Biomaterials, Seoul National University of Science and TechnologySeoul 01811Republic of KoreaSearch for other works by this author on:Insup NohInsup NohDepartment of Chemical and Biomolecular Engineering, Seoul National University of Science and TechnologySeoul 01811Republic of Korea[email protected]Convergence Institute of Biomedical Engineering and Biomaterials, Seoul National University of Science and TechnologySeoul 01811Republic of KoreaSearch for other works by this author on:
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Chapter 2: Introduction to Hydrogel Synthesis and Crosslinking Methods for Developing Bioinks for 3D Bioprintingp21-47ByGopinathan Janarthanan;Gopinathan JanarthananDepartment of Chemical and Biomolecular Engineering, Seoul National University of Science and TechnologySeoul 01811Republic of Korea[email protected]Convergence Institute of Biomedical Engineering and Biomaterials, Seoul National University of Science and TechnologySeoul 01811Republic of KoreaSearch for other works by this author on:Thambi Thavasyappan;Thambi ThavasyappanDepartment of Bioengineering, Hanyang UniversitySeoulRepublic of KoreaSearch for other works by this author on:SeongYeon Hong;SeongYeon HongDepartment of Chemical and Biomolecular Engineering, Seoul National University of Science and TechnologySeoul 01811Republic of Korea[email protected]Search for other works by this author on:Insup NohInsup NohDepartment of Chemical and Biomolecular Engineering, Seoul National University of Science and TechnologySeoul 01811Republic of Korea[email protected]Convergence Institute of Biomedical Engineering and Biomaterials, Seoul National University of Science and TechnologySeoul 01811Republic of KoreaSearch for other works by this author on:
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Chapter 3: Characterizations of Hydrogelsp48-76ByHye Jin Hong;Hye Jin HongDepartment of Chemical and Biomolecular Engineering, Yonsei University50 Yonsei-ro, Seodaemun-guSeoul120–749Republic of Korea[email protected]Search for other works by this author on:Won-Gun KohWon-Gun KohDepartment of Chemical and Biomolecular Engineering, Yonsei University50 Yonsei-ro, Seodaemun-guSeoul120–749Republic of Korea[email protected]Search for other works by this author on:
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Chapter 4: Naturally Occurring and Nature-derived Polymers as Injectable Hydrogelsp77-111ByLorenza DraghiLorenza DraghiDepartment of Chemistry, Materials and Chemical Engineering, Politecnico di Milano – via Mancinelli7 – 20131 MilanoItaly[email protected]Search for other works by this author on:
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Chapter 5: Self-assembling Hydrogels Based on Natural Building Blocksp112-140ByCharlotte Martin;Charlotte MartinResearch Group of Organic Chemistry (ORGC), Faculty of Science and Bio-engineering Sciences, Vrije Universiteit Brussel (VUB)Pleinlaan 21050 BrusselsBelgium[email protected][email protected]Search for other works by this author on:Steven BalletSteven BalletResearch Group of Organic Chemistry (ORGC), Faculty of Science and Bio-engineering Sciences, Vrije Universiteit Brussel (VUB)Pleinlaan 21050 BrusselsBelgium[email protected][email protected]Search for other works by this author on:
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Chapter 6: In Situ Forming Hydrogelsp141-154ByJiaju Lu;Jiaju LuSchool of Materials Science and Engineering, Zhejiang Sci-Tech University5 Second Avenue, Xiasha Higher Education ZoneHangzhou310018China[email protected]State Key Laboratory of New Ceramics and Fine Processing, School of Materials Science and Engineering, Tsinghua University, Haidian DistrictBeijing100084China[email protected]Search for other works by this author on:Xiangdong Kong;Xiangdong KongSchool of Materials Science and Engineering, Zhejiang Sci-Tech University5 Second Avenue, Xiasha Higher Education ZoneHangzhou310018China[email protected]Search for other works by this author on:Xiumei WangXiumei WangState Key Laboratory of New Ceramics and Fine Processing, School of Materials Science and Engineering, Tsinghua University, Haidian DistrictBeijing100084China[email protected]Search for other works by this author on:
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Chapter 7: Injectable Biopolymer Hydrogels for Regenerative Medicinep155-200ByXiaoyi Zhang;Xiaoyi ZhangNational Engineering Laboratory for Modern Silk & Collaborative Innovation Center of Suzhou Nano Science and Technology, Soochow UniversitySuzhou 215123People's Republic of China[email protected]Search for other works by this author on:Qingqing Lu;Qingqing LuNational Engineering Laboratory for Modern Silk & Collaborative Innovation Center of Suzhou Nano Science and Technology, Soochow UniversitySuzhou 215123People's Republic of China[email protected]Search for other works by this author on:Zhaozhao Ding;Zhaozhao DingNational Engineering Laboratory for Modern Silk & Collaborative Innovation Center of Suzhou Nano Science and Technology, Soochow UniversitySuzhou 215123People's Republic of China[email protected]Department of Burns and Plastic Surgery, The Affiliated Hospital of Jiangnan UniversityWuxi 214041People's Republic of ChinaSearch for other works by this author on:Weinan Cheng;Weinan ChengDepartment of Orthopedics, the First Affiliated Hospital of Xiamen UniversityXiamen 361000People's Republic of ChinaSearch for other works by this author on:Liying Xiao;Liying XiaoNational Engineering Laboratory for Modern Silk & Collaborative Innovation Center of Suzhou Nano Science and Technology, Soochow UniversitySuzhou 215123People's Republic of China[email protected]Search for other works by this author on:Qiang LuQiang LuNational Engineering Laboratory for Modern Silk & Collaborative Innovation Center of Suzhou Nano Science and Technology, Soochow UniversitySuzhou 215123People's Republic of China[email protected]Search for other works by this author on:
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Chapter 8: Hydrogel Processing Techniques and Vascular Tissue Engineeringp207-237ByN. Pien;N. PienLaboratory for Biomaterials and Bioengineering, Department of Min-Met-Materials Engineering & Regenerative Medicine, CHU de Quebec Research Center, Laval University2325 Rue de l'UniversitéQuébec G1V 0A6Canada[email protected]Polymer Chemistry & Biomaterials Research Group, Centre of Macromolecular Chemistry (CMaC), Ghent UniversityKrijgslaan 281, S4 bis9000 GhentBelgium[email protected]Search for other works by this author on:S. Van Vlierberghe;S. Van VlierberghePolymer Chemistry & Biomaterials Research Group, Centre of Macromolecular Chemistry (CMaC), Ghent UniversityKrijgslaan 281, S4 bis9000 GhentBelgium[email protected]Search for other works by this author on:P. Dubruel;P. DubruelPolymer Chemistry & Biomaterials Research Group, Centre of Macromolecular Chemistry (CMaC), Ghent UniversityKrijgslaan 281, S4 bis9000 GhentBelgium[email protected]Search for other works by this author on:D. MantovaniD. MantovaniLaboratory for Biomaterials and Bioengineering, Department of Min-Met-Materials Engineering & Regenerative Medicine, CHU de Quebec Research Center, Laval University2325 Rue de l'UniversitéQuébec G1V 0A6Canada[email protected]Search for other works by this author on:
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Chapter 9: Rheological Aspects of Hydrogel Processingp238-266ByT. De Maeseneer;T. De MaeseneerSoft Matter, Rheology, and Technology, Department of Chemical EngineeringKU Leuven, Celestijnenlaan 200J, P.O. Box 24243001 HeverleeBelgium[email protected]Search for other works by this author on:R. CardinaelsR. CardinaelsSoft Matter, Rheology, and Technology, Department of Chemical EngineeringKU Leuven, Celestijnenlaan 200J, P.O. Box 24243001 HeverleeBelgium[email protected]Polymer Technology, Department of Mechanical Engineering, Eindhoven University of TechnologyP.O. Box 5135600 MB EindhovenThe NetherlandsSearch for other works by this author on:
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Chapter 10: Interface (Cell, Gel, Surface) and Biocompatibility in Gel Processingp267-291ByAnnalisa La Gatta;Annalisa La GattaDepartment of Experimental Medicine, School of Medicine, University of Campania “Luigi Vanvitelli”Via L. De Crecchio 780138 NaplesItaly[email protected][email protected]Search for other works by this author on:Chiara SchiraldiChiara SchiraldiDepartment of Experimental Medicine, School of Medicine, University of Campania “Luigi Vanvitelli”Via L. De Crecchio 780138 NaplesItaly[email protected][email protected]Search for other works by this author on:
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Chapter 11: Bioprinting Hydrogels and Tissue Engineeringp292-315ByA. J. Melchiorri;A. J. MelchiorriBiomaterials Lab, Rice UniversityHoustonTX 77005USANIH/NIBIB Center for Engineering Complex TissuesBethesdaMD 20892USASearch for other works by this author on:A. G. MikosA. G. MikosBiomaterials Lab, Rice UniversityHoustonTX 77005USANIH/NIBIB Center for Engineering Complex TissuesBethesdaMD 20892USASearch for other works by this author on:
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Chapter 12: 3D Bioprinting Hydrogel for Hard Tissue Regenerationp316-338ByBaosen Tan;Baosen TanKey Laboratory for Biomechanics and Mechanobiology of Ministry of Education, Beijing Advanced Innovation Center for Biomedical Engineering, School of Biological Science and Medical Engineering, Beihang UniversityBeijing 100083China[email protected]Search for other works by this author on:Wenyong Liu;Wenyong LiuKey Laboratory for Biomechanics and Mechanobiology of Ministry of Education, Beijing Advanced Innovation Center for Biomedical Engineering, School of Biological Science and Medical Engineering, Beihang UniversityBeijing 100083China[email protected]Search for other works by this author on:Shaolong Kuang;Shaolong KuangRobotics and Micro-Systems Center, Soochow UniversitySuzhou 215021ChinaSearch for other works by this author on:Xiaoming LiXiaoming LiKey Laboratory for Biomechanics and Mechanobiology of Ministry of Education, Beijing Advanced Innovation Center for Biomedical Engineering, School of Biological Science and Medical Engineering, Beihang UniversityBeijing 100083China[email protected]Search for other works by this author on:
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Chapter 13: 3D-bioprinting for Engineering Complex Tissues and Vascularizationp339-359ByXinyun Zhai;Xinyun ZhaiNankai Univ, Sch Mat Sci & Engn, Tianjin Key Lab Rare Earth Mat & Applicat, Natl Inst Adv Mat, Ctr Rare Earth & Inorgan FunctTianjin 300350PR ChinaSearch for other works by this author on:Wenguang LiuWenguang LiuTianjin Univ, Sch Mat Sci & Engn, Tianjin Key Lab Composite & Funct MatTianjin 300350PR China[email protected]Search for other works by this author on:
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Chapter 14: Hydrogels–Blood Interactionsp361-382ByF. A. Jerca;F. A. JercaCentre of Organic Chemistry “Costin D. Nenitzescu” Romanian AcademySpl. Independentei 202B060023 BucharestRomaniaSearch for other works by this author on:I. C. Stancu;I. C. StancuAdvanced Polymer Materials Group, University Politehnica of Bucharest1-7 Gh Polizu Street011061 BucharestRomaniaFaculty of Medical Engineering, University Politehnica of Bucharest1-7 Gh Polizu Street011061 BucharestRomaniaSearch for other works by this author on:V. V. Jerca;V. V. JercaCentre of Organic Chemistry “Costin D. Nenitzescu” Romanian AcademySpl. Independentei 202B060023 BucharestRomaniaSearch for other works by this author on:E. D. GiolE. D. Giol“Cantacuzino” National Medico-Military Institute for Research and Development103 Splaiul Independentei StreetBucharest 050096Romania[email protected]Search for other works by this author on:
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Chapter 15: Immuno-response and Hydrogelsp383-392ByHyeong-Cheol Yang;Hyeong-Cheol YangDepartment of Dental Biomaterials Science and Dental Research Institute, School of Dentistry, Seoul National University101 Daehak-ro, Jongno-guSeoul 03080Korea[email protected]Search for other works by this author on:Yongjoon Kim;Yongjoon KimDepartment of Dental Biomaterials Science and Dental Research Institute, School of Dentistry, Seoul National University101 Daehak-ro, Jongno-guSeoul 03080Korea[email protected]Search for other works by this author on:Lele WuLele WuDepartment of Dental Biomaterials Science and Dental Research Institute, School of Dentistry, Seoul National University101 Daehak-ro, Jongno-guSeoul 03080Korea[email protected]Search for other works by this author on:
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Chapter 16: Application of Natural Hydrogels for Cell Therapy: Focus on Osteoarthritisp393-408ByChangsu Kim;Changsu KimDepartment of Orthopedics Surgery, Kosin University Gospel Hospital262 Gamcheon-ro, Seo-guBusan 49267Republic of KoreaSearch for other works by this author on:Sang-Hyug ParkSang-Hyug ParkDepartment of Biomedical Engineering, Pukyong National University45 Yongso-ro, Nam-GuBusan 48513Republic of Korea[email protected]Search for other works by this author on:
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Chapter 17: Clinical Application and Regulation of Bioprinting Biomaterials Focusing on Hydrogelsp409-438ByJ. H. Jeon;J. H. JeonDepartment of Otolaryngology-Head and Neck Surgery, Seoul ST. Mary's Hospital, The Catholic University of KoreaBanpo-Daero, Seocho-guSeoul137-701Republic of Korea[email protected]Search for other works by this author on:J. Y. Lim;J. Y. LimDepartment of Otolaryngology-Head and Neck Surgery, Seoul ST. Mary's Hospital, The Catholic University of KoreaBanpo-Daero, Seocho-guSeoul137-701Republic of Korea[email protected]Search for other works by this author on:S. W. KimS. W. KimDepartment of Otolaryngology-Head and Neck Surgery, Seoul ST. Mary's Hospital, The Catholic University of KoreaBanpo-Daero, Seocho-guSeoul137-701Republic of Korea[email protected]Search for other works by this author on:
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Chapter 18: Status for Commercialization of FDA-approved Hydrogels and Their Intellectual Propertiesp439-474ByAmitava Bhattacharyya;Amitava BhattacharyyaFunctional, Innovative and Smart Textiles, PSG Institute of Advanced StudiesCoimbatore – 641004IndiaDepartment of Chemical and Biomolecular Engineering, Seoul National University of Science and TechnologySeoul 01811Republic of Korea[email protected]Convergence Institute of Biomedical Engineering and Biomaterials, Seoul National University of Science and TechnologySeoul 01811Republic of KoreaSearch for other works by this author on:Gopinathan Janarthanan;Gopinathan JanarthananDepartment of Chemical and Biomolecular Engineering, Seoul National University of Science and TechnologySeoul 01811Republic of Korea[email protected]Convergence Institute of Biomedical Engineering and Biomaterials, Seoul National University of Science and TechnologySeoul 01811Republic of KoreaSearch for other works by this author on:Julie Kang;Julie KangBiochemistry, University of MichiganAnn ArborMI 48109USASearch for other works by this author on:Insup NohInsup NohDepartment of Chemical and Biomolecular Engineering, Seoul National University of Science and TechnologySeoul 01811Republic of Korea[email protected]Convergence Institute of Biomedical Engineering and Biomaterials, Seoul National University of Science and TechnologySeoul 01811Republic of KoreaSearch for other works by this author on:
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