Advanced Fragmentation Methods in Biomolecular Mass Spectrometry: Probing Primary and Higher Order Structure with Electrons, Photons and Surfaces
Breaking down large biomolecules into fragments in a controlled manner is key to modern biomolecular mass spectrometry. This book is a high-level introduction, as well as a reference work for experienced users, to ECD, ETD, EDD, NETD, UVPD, SID, and other advanced fragmentation methods. It provides a comprehensive overview of their history, mechanisms, instrumentation, and key applications. With contributions from leading experts, this book will act as an authoritative guide to these methods.
Aimed at postgraduate and professional researchers, mainly in academia, but also in industry, it can be used as supplementary reading for advanced students on mass spectrometry or analytical (bio)chemistry courses.
Advanced Fragmentation Methods in Biomolecular Mass Spectrometry: Probing Primary and Higher Order Structure with Electrons, Photons and Surfaces, The Royal Society of Chemistry, 2020.
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Table of contents
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Chapter 1: Modern Mass Spectrometry and Advanced Fragmentation Methodsp1-14ByFrederik LermyteFrederik LermyteDepartment of Chemistry, Institute of Chemistry and Biochemistry, Technical University of Darmstadt64287 DarmstadtGermany[email protected]Mass Spectrometry Laboratory, MolSys Research Unit, University of Liège4000 LiègeBelgiumSchool of Engineering, University of WarwickCoventry CV4 7ALUKSearch for other works by this author on:
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Chapter 2: Mechanism and Implementation of Electron Capture and Electron Transfer Dissociationp15-32ByFrederik LermyteFrederik LermyteDepartment of Chemistry, Institute of Chemistry and Biochemistry, Technical University of Darmstadt64287 DarmstadtGermany[email protected]Mass Spectrometry Laboratory, MolSys Research Unit, University of Liège4000 LiègeBelgiumSchool of Engineering, University of WarwickCoventry CV4 7ALUKSearch for other works by this author on:
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Chapter 3: ECD/ETD for Sequencing of Peptides and Denatured Proteinsp33-71ByTimothy K. TobyTimothy K. TobyFeinberg School of Medicine, Northwestern UniversityEvanstonILUSASearch for other works by this author on:
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Chapter 4: Structural Studies using Electron-based Fragmentation Methods and Chemical Labelling of Proteinsp72-101ByFrank SobottFrank SobottSearch for other works by this author on:
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Chapter 5: Investigating 3D Structures of Native Proteins and Complexes through Electron-based Dissociationp102-133ByJoseph A. Loo;Joseph A. LooDepartment of Chemistry and Biochemistry, University of California-Los AngelesLos AngelesCAUSA[email protected]Search for other works by this author on:Andrew K. Goring;Andrew K. GoringDepartment of Chemistry and Biochemistry, University of California-Los AngelesLos AngelesCAUSA[email protected]Search for other works by this author on:Carter Lantz;Carter LantzDepartment of Chemistry and Biochemistry, University of California-Los AngelesLos AngelesCAUSA[email protected]Search for other works by this author on:Benqian Wei;Benqian WeiDepartment of Chemistry and Biochemistry, University of California-Los AngelesLos AngelesCAUSA[email protected]Search for other works by this author on:Muhammad A. ZenaideeMuhammad A. ZenaideeDepartment of Chemistry and Biochemistry, University of California-Los AngelesLos AngelesCAUSA[email protected]Search for other works by this author on:
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Chapter 6: Electron Detachment Dissociation (EDD) and Negative Electron Transfer Dissociation (NETD)p134-170ByI. Jonathan AmsterI. Jonathan AmsterSearch for other works by this author on:
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Chapter 7: Electron Photodetachment and the Radical Fragmentation Route for Negative Ionsp171-194ByEdwin De PauwEdwin De PauwSearch for other works by this author on:
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Chapter 8: Elucidating Biomolecular Structure Through Bond-selective Radical Fragmentationp195-208ByEvan E. Hubbard;Evan E. HubbardDepartment of Chemistry, University of California, Riverside501 Big Spring RoadRiversideCalifornia 92521United States[email protected]Search for other works by this author on:Ryan R. JulianRyan R. JulianDepartment of Chemistry, University of California, Riverside501 Big Spring RoadRiversideCalifornia 92521United States[email protected]Search for other works by this author on:
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Chapter 9: Structural Analysis of Lipids Using Advanced Tandem MS Methodsp209-234BySimin Cheng;Simin ChengState Key Laboratory of Precision Measurement Technology and Instruments, Department of Precision Instrument, Tsinghua UniversityBeijing 100084China[email protected]Search for other works by this author on:Xu Zhao;Xu ZhaoDepartment of Chemistry, Tsinghua UniversityBeijing 100084ChinaSearch for other works by this author on:Xiaoxiao MaXiaoxiao MaState Key Laboratory of Precision Measurement Technology and Instruments, Department of Precision Instrument, Tsinghua UniversityBeijing 100084China[email protected]Search for other works by this author on:
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Chapter 10: Photoactivation and Dissociation in Biomolecular Mass Spectrometryp235-280ByRachelle Black;Rachelle BlackManchester Institute of Biotechnology, Department of Chemistry, University of ManchesterManchesterM1 7DNUK[email protected]Search for other works by this author on:Perdita E. Barran;Perdita E. BarranManchester Institute of Biotechnology, Department of Chemistry, University of ManchesterManchesterM1 7DNUK[email protected]Search for other works by this author on:Lennart A. I. RamakersLennart A. I. RamakersManchester Institute of Biotechnology, Department of Chemistry, University of ManchesterManchesterM1 7DNUK[email protected]Search for other works by this author on:
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Chapter 11: Surface-induced Dissociation in Biomolecular Mass Spectrometryp281-336ByVicki H. WysockiVicki H. WysockiSearch for other works by this author on:
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