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Recently, metal–organic frameworks (MOFs) have exhibited great application potential in many fields due to their high porosity, as well as well-defined channels with tunable size, shape, and environment. However, the limited processibility as well as poor electrical conductivity and biosafety hinder their further applications in separation, electrochemistry, biomedicine, etc. Hybridizing polymers with MOFs is an effective way to overcome these shortcomings. The flexibility, optoelectronic properties, biocompatibility, and other features of polymers bring new traits and functions to the hybrid materials. In this chapter, the applications of MOF/polymer hybrid materials in electrochemistry, toxic chemical protection, and biomedicine are summarized. In addition, we also discuss the challenges and future research directions of MOF hybrids in these fields.

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