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Microfluidic systems, as a miniaturized form of regular laboratories, have been advanced quickly and offer useful and numerous applications in analytical, biomedical and life sciences. Using such systems, a complete diagnostic protocol is performable automatically into the miniaturized chip, providing improved analytical performance and throughput, reduced reagent/sample consumption and amount of generated waste, high portability, low power consumption, low cost and short analysis times, small instrumental footprint and decreased risk of contamination, high sensitivity and resolution as well as improved reliability. These advantages induce the further development of lab-on-a-chip systems. The huge number of publications in this area illustrates the increased interest in microfluidics topics. This chapter focuses on the application of microfluidic analytical devices advanced for the measurement of antioxidants in different samples. The innovations and advances in these systems have led to great improvements in the analysis of antioxidants. In the following we classified the reported analytical systems into two main categories: the first class is related to the microfluidic analytical devices developed for the analysis of total antioxidant capacity and the second class describes the reports for the analysis of individual antioxidants.

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