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New Developments in Mass Spectrometry
Ion Mobility – Mass Spectrometry: Fundamentals and Applications
Edited by
Alison E Ashcroft;
Alison E Ashcroft
University of Leeds, UK
Search for other works by this author on:
Frank Sobott
Frank Sobott
University of Leeds, UK
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Hardback ISBN:
978-1-83916-166-7
PDF ISBN:
978-1-83916-288-6
EPUB ISBN:
978-1-83916-289-3
Special Collection:
2021 ebook collection
No. of Pages:
476
Publication date:
11 Nov 2021
About this book
Over the last decade, the use of ion mobility separation in combination with mass spectrometry analysis has developed significantly. This technique adds a unique extra dimension enabling the in-depth analysis of a wide range of complex samples in the areas of the chemical and biological sciences. Providing a comprehensive guide to the technique, each chapter is written by an internationally recognised expert and with numerous different commercial platforms to choose from, this book will help the end users understand the practicalities of using different instruments for different ion mobility purposes.
The first section provides a detailed account of the fundamentals behind the technique and the current range of available instrumentation. The second section focusses on the wide range of applications that have benefitted from ion mobility – mass spectrometry and includes topics taken from current research in the pharmaceutical, metabolomics, glycomics, and structural molecular biology fields. The book is primarily aimed at researchers, appealing to practising chemists and biochemists, as well as those in the pharmaceutical and medical fields.
Ion Mobility – Mass Spectrometry: Fundamentals and Applications, The Royal Society of Chemistry, 2021.
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Digital access
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Ion Mobility-Mass Spectrometry
$235.00
Table of contents
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CHAPTER 1: Ion Mobility–Mass Spectrometry: an Overviewp1-25ByValérie GabelicaValérie GabelicaSearch for other works by this author on:
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CHAPTER 2: Calculation of Momentum Transfer Cross-sectionsp26-51ByC. Bleiholder;C. BleiholderDepartment of Chemistry and Biochemistry, Institute of Molecular Biophysics, Florida State UniversityFlorida, Tallahassee 32306USA[email protected]Search for other works by this author on:F. C. Liu;F. C. LiuDepartment of Chemistry and Biochemistry, Institute of Molecular Biophysics, Florida State UniversityFlorida, Tallahassee 32306USA[email protected]Search for other works by this author on:M. ChaiM. ChaiDepartment of Chemistry and Biochemistry, Institute of Molecular Biophysics, Florida State UniversityFlorida, Tallahassee 32306USA[email protected]Search for other works by this author on:
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CHAPTER 3: Fundamentals of Uniform-field Drift Tube Ion Mobility and Collision Cross Sectionp52-82ByJ. C. FjeldstedJ. C. FjeldstedSearch for other works by this author on:
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CHAPTER 4: Travelling Wave Ion Mobility Separation: Basics and Calibrationp83-104ByK. GilesK. GilesSearch for other works by this author on:
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CHAPTER 5: Trapped Ion Mobility Spectrometry – Basics and Calibrationp105-131ByM. ParkM. ParkSearch for other works by this author on:
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CHAPTER 6: Field Asymmetric Ion Mobility Spectrometry (FAIMS) for Advanced Mass Spectrometryp132-162ByE. Bonneil;E. BonneilInstitute for Research in Immunology and CancerMontréalCanadaSearch for other works by this author on:J. Lanoix;J. LanoixInstitute for Research in Immunology and CancerMontréalCanadaSearch for other works by this author on:C. Durette;C. DuretteInstitute for Research in Immunology and CancerMontréalCanadaSearch for other works by this author on:P. Thibault;P. ThibaultInstitute for Research in Immunology and CancerMontréalCanadaDepartment of Chemistry, Université de MontréalMontréalCanadaSearch for other works by this author on:R. D. Melani;R. D. MelaniChemistry of Life Processes Institute; and the Proteomics Center of Excellence, Northwestern UniversityEvanstonILUSASearch for other works by this author on:K. Srzentić;K. SrzentićThermo Fisher ScientificCambridgeMAUSASearch for other works by this author on:L. Fornelli;L. FornelliDepartment of Biology, University of OklahomaNormanOKUSASearch for other works by this author on:N. L. Kelleher;N. L. KelleherChemistry of Life Processes Institute; and the Proteomics Center of Excellence, Northwestern UniversityEvanstonILUSASearch for other works by this author on:R. W. Purves;R. W. PurvesCanadian Food Inspection AgencySaskatoonSKCanadaUniversity of SaskatchewanSaskatoonSKCanadaSearch for other works by this author on:G. de Albuquerque Cavalcanti;G. de Albuquerque CavalcantiUniversidade Federal do Rio de Janeiro (UFRJ), Instituto de Química (IQ) Brazilian Doping Control Laboratory–LBCDRio de JaneiroBrazilSearch for other works by this author on:C. BoeserC. BoeserSearch for other works by this author on:
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CHAPTER 7: Computational Approaches for Processing Native Ion Mobility–Mass Spectrometry Datap163-182ByT. Cragnolini;T. CragnoliniInstitute of Structural and Molecular Biology, Division of Biosciences, University College LondonLondonWC1E 6BTUK[email protected]Institute of Structural and Molecular Biology, Birkbeck College, University of LondonLondonWC1E 7HXUK[email protected]Search for other works by this author on:K. ThalassinosK. ThalassinosInstitute of Structural and Molecular Biology, Division of Biosciences, University College LondonLondonWC1E 6BTUK[email protected]Institute of Structural and Molecular Biology, Birkbeck College, University of LondonLondonWC1E 7HXUK[email protected]Search for other works by this author on:
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CHAPTER 8: CCS for Modelling 3D Structuresp183-205ByM. T. Degiacomi;M. T. DegiacomiDepartment of Physics, Durham UniversityDurhamUKSearch for other works by this author on:A. Politis;A. PolitisDepartment of Chemistry, King's College LondonLondonUKSearch for other works by this author on:M. LandrehM. LandrehDepartment of Microbiology, Tumor and Cell Biology, Karolinska InstitutetStockholmSwedenSearch for other works by this author on:
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CHAPTER 9: Ion Spectroscopy Coupled to Ion Mobility–Mass Spectrometryp206-242ByIuliia Stroganova;Iuliia StroganovaDivision of BioAnalytical Chemistry, AIMMS Amsterdam Institute of Molecular and Life Sciences, Vrije Universiteit AmsterdamDe Boelelaan 11081081 HV AmsterdamThe Netherlands[email protected]Search for other works by this author on:Anouk M. RijsAnouk M. RijsDivision of BioAnalytical Chemistry, AIMMS Amsterdam Institute of Molecular and Life Sciences, Vrije Universiteit AmsterdamDe Boelelaan 11081081 HV AmsterdamThe Netherlands[email protected]Search for other works by this author on:
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CHAPTER 10: Ion Mobility–Mass Spectrometry of Pharmaceuticalsp243-271ByAndrew D. Ray;Andrew D. RayNew Modalities Product Development, Pharmaceutical Technology & Development, Operations, AstraZenecaMacclesfieldUK[email protected]Search for other works by this author on:Anthony W. T. Bristow;Anthony W. T. BristowChemical Development, Pharmaceutical Technology & Development, Operations, AstraZenecaMacclesfieldUKSearch for other works by this author on:Stephen W. HolmanStephen W. HolmanChemical Development, Pharmaceutical Technology & Development, Operations, AstraZenecaMacclesfieldUKSearch for other works by this author on:
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CHAPTER 11: Ion Mobility Spectrometry in Mass Spectrometry Imagingp272-306ByHelen J. CooperHelen J. CooperSearch for other works by this author on:
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CHAPTER 12: Ion Mobility–Mass Spectrometry in Metabolomics Studiesp307-335ByEmanuel Zlibut;Emanuel ZlibutDepartment of Chemistry, Center for Innovative Technology, Vanderbilt Institute of Chemical Biology, Vanderbilt Institute for Integrative Biosystems Research and Education, Vanderbilt-Ingram Cancer Center, Vanderbilt UniversityNashvilleTN 37235USA[email protected]Search for other works by this author on:Katrina L. Leaptrot;Katrina L. LeaptrotDepartment of Chemistry, Center for Innovative Technology, Vanderbilt Institute of Chemical Biology, Vanderbilt Institute for Integrative Biosystems Research and Education, Vanderbilt-Ingram Cancer Center, Vanderbilt UniversityNashvilleTN 37235USA[email protected]Search for other works by this author on:Jody C. May;Jody C. MayDepartment of Chemistry, Center for Innovative Technology, Vanderbilt Institute of Chemical Biology, Vanderbilt Institute for Integrative Biosystems Research and Education, Vanderbilt-Ingram Cancer Center, Vanderbilt UniversityNashvilleTN 37235USA[email protected]Search for other works by this author on:John A. McLeanJohn A. McLeanDepartment of Chemistry, Center for Innovative Technology, Vanderbilt Institute of Chemical Biology, Vanderbilt Institute for Integrative Biosystems Research and Education, Vanderbilt-Ingram Cancer Center, Vanderbilt UniversityNashvilleTN 37235USA[email protected]Search for other works by this author on:
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CHAPTER 13: The Role of Ion Mobility for Antibody Characterisation: A Biopharmaceutical Perspectivep336-366ByIain D. G. CampuzanoIain D. G. CampuzanoSearch for other works by this author on:
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CHAPTER 14: Insights into Membrane Protein Structure and Function by Means of Ion Mobility–Mass Spectrometryp367-401ByAnna J. Higgins;Anna J. HigginsAstbury Centre for Structural Molecular Biology, School of Molecular and Cellular Biology, Faculty of Biological Sciences, University of LeedsLeedsLS2 9JTUK[email protected]Search for other works by this author on:Antonio N. CalabreseAntonio N. CalabreseAstbury Centre for Structural Molecular Biology, School of Molecular and Cellular Biology, Faculty of Biological Sciences, University of LeedsLeedsLS2 9JTUK[email protected]Search for other works by this author on:
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CHAPTER 15: Conformational Characterisation of Biomoleculesp402-435ByRuth Knox;Ruth KnoxMichael Barber Centre for Collaborative Mass Spectrometry, Manchester Institute of Biotechnology and Photon Science Institute, University of ManchesterManchesterM1 7DNUK[email protected]Search for other works by this author on:Alexey Barkhanskiy;Alexey BarkhanskiyMichael Barber Centre for Collaborative Mass Spectrometry, Manchester Institute of Biotechnology and Photon Science Institute, University of ManchesterManchesterM1 7DNUK[email protected]Search for other works by this author on:Aidan P. France;Aidan P. FranceMichael Barber Centre for Collaborative Mass Spectrometry, Manchester Institute of Biotechnology and Photon Science Institute, University of ManchesterManchesterM1 7DNUK[email protected]Search for other works by this author on:Perdita E. BarranPerdita E. BarranMichael Barber Centre for Collaborative Mass Spectrometry, Manchester Institute of Biotechnology and Photon Science Institute, University of ManchesterManchesterM1 7DNUK[email protected]Search for other works by this author on:
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CHAPTER 16: Advanced IM-MS-based Approaches for Protein Analysis: Collision-induced Unfolding (CIU) and Hyphenation of Liquid Chromatography to IM-MSp436-460ByE. Deslignière;E. DeslignièreLaboratoire de Spectrométrie de Masse BioOrganique (LSMBO)IPHC, UMR 7178Université de StrasbourgCNRS67087 StrasbourgFrance[email protected]Infrastructure Nationale de ProtéomiqueProFI – FR2048 CNRS67087 StrasbourgFranceSearch for other works by this author on:O. Hernandez-Alba;O. Hernandez-AlbaLaboratoire de Spectrométrie de Masse BioOrganique (LSMBO)IPHC, UMR 7178Université de StrasbourgCNRS67087 StrasbourgFrance[email protected]Infrastructure Nationale de ProtéomiqueProFI – FR2048 CNRS67087 StrasbourgFranceSearch for other works by this author on:S. CianféraniS. CianféraniLaboratoire de Spectrométrie de Masse BioOrganique (LSMBO)IPHC, UMR 7178Université de StrasbourgCNRS67087 StrasbourgFrance[email protected]Infrastructure Nationale de ProtéomiqueProFI – FR2048 CNRS67087 StrasbourgFranceSearch for other works by this author on:
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CHAPTER 17: Ion Mobility–Mass Spectrometry of Nucleic Acidsp461-495ByDan FabrisDan FabrisDepartment of Chemistry, University of Connecticut55 North Eagleville Road, A416StorrsCT 06269-3060USA[email protected]Search for other works by this author on:
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CHAPTER 18: Glycomics and Ion Mobilityp496-517ByW. B. StruweW. B. StruweUniversity of Oxford, Department of Chemistry, Chemistry Research LaboratoryMansfield RoadOxfordOX1 3TAUKUniversity of Oxford, Department of Biochemistry, Glycobiology InstituteSouth Parks RoadOxfordOX1 3QUUK[email protected]Search for other works by this author on:
https://orcid.org/0000-0002-7446-9907
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