Chapter 12: Porphyrinoids Used for Photodynamic Inactivation against Bacteria
Published:10 Aug 2021
A. A. Glowacka-Sobotta, B. D. Ziental, and C. L. Sobotta, in Applications of Porphyrinoids as Functional Materials, ed. H. Lang and T. Rueffer, The Royal Society of Chemistry, 2021, ch. 12, pp. 352-404.
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Antibiotic resistance is a growing challenge for modern medicine. This problem requires searching for new solutions and opening new potential treatment methods. This chapter presents a comprehensive state-of-the-art analysis of photodynamic antimicrobial chemotherapy (PACT). The multidirectional way of action of photosensitizers based on the generation of reactive oxygen species makes it difficult for bacteria to develop a simple resistance mechanism. Due to these properties of PACT, this therapy may play an increasingly important role in the fight against bacterial infections in the near future. Undoubtedly, it is still necessary to intensify work on the clinical application of PACT.