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Gibbs Energy and Helmholtz Energy: Liquids, Solutions and Vapours
Edited by
Emmerich Wilhelm;
Emmerich Wilhelm
University of Vienna, Austria
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Trevor M Letcher
Trevor M Letcher
University of KwaZuluNatal, South Africa
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Hardback ISBN:
978-1-83916-201-5
PDF ISBN:
978-1-83916-409-5
EPUB ISBN:
978-1-83916-410-1
Special Collection:
2021 ebook collection
No. of Pages:
486
Published online:
08 Sep 2021
Published in print:
15 Sep 2021
Book Chapter
CHAPTER 12: Free Energy in Thermal and Chemical Protein Unfolding
By
J. Seelig
J. Seelig
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Published:08 Sep 2021
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Special Collection: 2021 ebook collection
Page range:
363 - 378
Citation
J. Seelig, in Gibbs Energy and Helmholtz Energy: Liquids, Solutions and Vapours, ed. E. Wilhelm and T. M. Letcher, The Royal Society of Chemistry, 2021, pp. 363-378.
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Protein stability is of the utmost importance for all aspects of life. Proteins will lose their biological function at high or low temperatures. Enthalpy–entropy compensation leads to a small free energy of protein unfolding. Three thermodynamic models are presented for hot and cold denaturation and are compared with experimental results obtained with differential scanning calorimetry.
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