Implantable Technologies: Peptides and Small Molecules Drug Delivery
Implantable technologies allow for a sustained control over the release of pharmaceuticals into the bloodstream thereby achieving a controlled concentration with the potential to minimise side-effects while increasing patient compliance. Significant progress has been made in various alternative implantable delivery technologies, notably in intraocular and subcutaneous devices. Despite success in research and clinical studies, long-term clinical efficacy may be more limited and different aspects related to drug development and commercialization using these technologies are not well understood or practiced in the commercial setting. This book provides a comprehensive and cohesive picture of the latest in the field while also outlining the opportunities and challenges in implantable technology. Implantable Technologies: Pepties and Biologic Drug Development is an ideal reference for any postgraduate or researcher interested in utilising implantable technologies and novel routes of drug administration. The book will also be of interest to those involved in formulation and clinical application for a wide array of disease areas in addition to more established paradigms such as diabetes and pain management.
Implantable Technologies: Peptides and Small Molecules Drug Delivery, The Royal Society of Chemistry, 2021.
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Table of contents
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Status of Implantable and Long-acting Injectable Technologiesp1-13ByVed SrivastavaVed SrivastavaSearch for other works by this author on:
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CHAPTER 2: Developing Complex Dosage Forms of Long-acting Biologics for the Eye: Current State, Challenges, and Opportunitiesp14-53ByPatrick Hughes;Patrick HughesGlaukos229 Avenida FabricanteSan ClementeCA 92672USASearch for other works by this author on:Christopher A. Rhodes;Christopher A. RhodesDrug Delivery Experts11494 Sorrento Valley Road, Suite JSan DiegoCA 92121USASearch for other works by this author on:Hongwen M. RiversHongwen M. RiversSearch for other works by this author on:
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CHAPTER 3: Monolithic Devices for Sustained Delivery of Protein Therapeutics for Ocular Diseasep54-75ByTannia M. Rodriguez;Tannia M. RodriguezDepartment of Bioengineering and Therapeutic Sciences, University of California, San Francisco (UCSF)1700 4th StreetSan FranciscoCA 94158USA[email protected]Search for other works by this author on:Daniel A. Bernards;Daniel A. BernardsDepartment of Bioengineering and Therapeutic Sciences, University of California, San Francisco (UCSF)1700 4th StreetSan FranciscoCA 94158USA[email protected]Search for other works by this author on:Tejal A. DesaiTejal A. DesaiDepartment of Bioengineering and Therapeutic Sciences, University of California, San Francisco (UCSF)1700 4th StreetSan FranciscoCA 94158USA[email protected]Search for other works by this author on:
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CHAPTER 4: Sustained Delivery of Ocular Protein Therapeuticsp76-89ByChunwan Yen;Chunwan YenSmall Molecule Pharmaceutical Sciences, GenentechSouth San FranciscoCaliforniaUSASearch for other works by this author on:Shrirang Ranade;Shrirang RanadePharma Technical Development, GenentechSouth San FranciscoCaliforniaUSASearch for other works by this author on:Giulio Barteselli;Giulio BarteselliOphthalmology Product Development, GenentechSouth San FranciscoCaliforniaUSASearch for other works by this author on:Rami N. HannoushRami N. HannoushDepartment of Early Discovery Biochemistry, GenentechSouth San FranciscoCaliforniaUSA[email protected]Search for other works by this author on:
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CHAPTER 5: Development of Risperidone Implant Formulations (DLP-114) for Long-term Maintenance Treatment of Schizophreniap90-110ByFrancis MartinFrancis MartinSearch for other works by this author on:
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CHAPTER 6: In-line Extrusion Process and Product Evaluation of ProNeura® by Near-infrared Spectroscopyp111-130ByRaj PatelRaj PatelSearch for other works by this author on:
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CHAPTER 7: Addressing Immunogenicity for Implantable Drug-delivery Devices and Long-acting Injectables, Including Pharmacokinetic and Pharmacodynamic Correlationsp131-159ByJames MatrianoJames MatrianoSearch for other works by this author on:
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CHAPTER 8: Characterization Methods for Parenteral Peptide Controlled Release Drug Delivery Systemsp160-187ByKarsten MäderKarsten MäderSearch for other works by this author on:
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CHAPTER 9: Parenteral Delivery of Therapeutic Proteins, Peptides and Small Molecules Using Biodegradable Silicap188-215ByL. LeinoL. LeinoSearch for other works by this author on:
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CHAPTER 10: Development of User-initiated Vaginal Dosage Formsp216-251ByThomas M. ZydowskyThomas M. ZydowskySearch for other works by this author on:
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CHAPTER 11: Three-dimensional Printed Implantable Productsp252-295ByThomas McDonaghThomas McDonaghSearch for other works by this author on:
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