Alzheimer's Disease: Recent Findings in Pathophysiology, Diagnostic and Therapeutic Modalities
Alzheimer’s disease is an increasingly common form of dementia and despite rising interest in discovery of novel treatments and investigation into aetiology, there are no currently approved treatments that directly tackle the causes of the condition. Due to its multifactorial pathogenesis, current treatments are directed against symptoms and even precise diagnosis remains difficult as the majority of cases are diagnosed symptomatically and usually confirmed only by autopsy. Alzheimer’s Disease: Recent Findings in Pathophysiology, Diagnostic and Therapeutic Modalities provides a comprehensive overview from aetiology and neurochemistry to diagnosis, evaluation and management of Alzheimer's disease, and latest therapeutic approaches. Intended to provide an introduction to all aspects of the disease and latest developments, this book is ideal for students, postgraduates and researchers in neurochemistry, neurological drug discovery and Alzheimer’s disease.
Alzheimer's Disease: Recent Findings in Pathophysiology, Diagnostic and Therapeutic Modalities, The Royal Society of Chemistry, 2022.
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Chapter 1: Alzheimer's is a Multifactorial Diseasep1-34BySourav Samanta;Sourav SamantaBioorganic Chemistry laboratory, New Chemistry Unit, Jawaharlal Nehru Centre for Advanced Scientific Research (JNCASR)Bengaluru 560064India[email protected]Search for other works by this author on:Madhu Ramesh;Madhu RameshBioorganic Chemistry laboratory, New Chemistry Unit, Jawaharlal Nehru Centre for Advanced Scientific Research (JNCASR)Bengaluru 560064India[email protected]Search for other works by this author on:Thimmaiah GovindarajuThimmaiah GovindarajuBioorganic Chemistry laboratory, New Chemistry Unit, Jawaharlal Nehru Centre for Advanced Scientific Research (JNCASR)Bengaluru 560064India[email protected]Search for other works by this author on:
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Chapter 2: The Genetic and Biochemical Basis of Alzheimer's Diseasep35-57ByKottapalli Srividya;Kottapalli SrividyaDivision of Neuroscience and Ageing Biology, CSIR-Central Drug Research InstituteLucknow-226031India[email protected]Search for other works by this author on:Aamir NazirAamir NazirDivision of Neuroscience and Ageing Biology, CSIR-Central Drug Research InstituteLucknow-226031India[email protected]Search for other works by this author on:
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Chapter 3: Alzheimer's Disease Pathology: A Tau Perspectivep58-88ByShweta Kishor Sonawane;Shweta Kishor SonawaneNeurobiology Group, Division of Biochemical Sciences, CSIR-National Chemical Laboratory, DrHomi Bhabha RoadPune411008India[email protected]Academy of Scientific and Innovative Research (AcSIR)Ghaziabad201002IndiaSearch for other works by this author on:Tushar Dubey;Tushar DubeyNeurobiology Group, Division of Biochemical Sciences, CSIR-National Chemical Laboratory, DrHomi Bhabha RoadPune411008India[email protected]Academy of Scientific and Innovative Research (AcSIR)Ghaziabad201002IndiaSearch for other works by this author on:Abhishek Ankur Balmik;Abhishek Ankur BalmikNeurobiology Group, Division of Biochemical Sciences, CSIR-National Chemical Laboratory, DrHomi Bhabha RoadPune411008India[email protected]Academy of Scientific and Innovative Research (AcSIR)Ghaziabad201002IndiaSearch for other works by this author on:Rashmi Das;Rashmi DasNeurobiology Group, Division of Biochemical Sciences, CSIR-National Chemical Laboratory, DrHomi Bhabha RoadPune411008India[email protected]Academy of Scientific and Innovative Research (AcSIR)Ghaziabad201002IndiaSearch for other works by this author on:Subashchandrabose ChinnathambiSubashchandrabose ChinnathambiNeurobiology Group, Division of Biochemical Sciences, CSIR-National Chemical Laboratory, DrHomi Bhabha RoadPune411008India[email protected]Academy of Scientific and Innovative Research (AcSIR)Ghaziabad201002IndiaSearch for other works by this author on:
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Chapter 4: Structural Insights Into the Amyloidogenic Aβ and Tau Species in Alzheimer's disease Pathophysiology: Defining Functional Motifs for Therapeutic Interventionsp89-114ByDibakar Sarkar;Dibakar SarkarDepartment of Biophysics, Bose Institute, P-1/12 CIT Scheme VII (M)Kolkata 700054India[email protected][email protected]Search for other works by this author on:Anirban BhuniaAnirban BhuniaDepartment of Biophysics, Bose Institute, P-1/12 CIT Scheme VII (M)Kolkata 700054India[email protected][email protected]Search for other works by this author on:
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Chapter 5: Structural Insights on Aggregation Species of Aβ and Tau, and Their Implications in Alzheimer's Diseasep115-136ByDan Li;Dan LiBio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders, Ministry of Education, Shanghai Jiao Tong UniversityShanghai200030China[email protected]Bio-X-Renji Hospital Research Center, Renji Hospital, School of Medicine, Shanghai Jiao Tong UniversityShanghai 200240ChinaSearch for other works by this author on:Cong LiuCong LiuInterdisciplinary Research Center on Biology and Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of SciencesShanghai 201203China[email protected]Search for other works by this author on:
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Chapter 6: Aggregation Species of Amyloid-β and Tau Oligomers in Alzheimer's Disease: Role in Therapeutics and Diagnosticsp137-169ByAbhishek Ankur Balmik;Abhishek Ankur BalmikNeurobiology Group, Division of Biochemical Sciences, CSIR-National Chemical LaboratoryDr Homi Bhabha RoadPune411008India[email protected]Academy of Scientific and Innovative Research (AcSIR)Ghaziabad201002IndiaSearch for other works by this author on:Rashmi Das;Rashmi DasNeurobiology Group, Division of Biochemical Sciences, CSIR-National Chemical LaboratoryDr Homi Bhabha RoadPune411008India[email protected]Academy of Scientific and Innovative Research (AcSIR)Ghaziabad201002IndiaSearch for other works by this author on:Shweta Kishor Sonawane;Shweta Kishor SonawaneNeurobiology Group, Division of Biochemical Sciences, CSIR-National Chemical LaboratoryDr Homi Bhabha RoadPune411008India[email protected]Academy of Scientific and Innovative Research (AcSIR)Ghaziabad201002IndiaSearch for other works by this author on:Subashchandrabose ChinnathambiSubashchandrabose ChinnathambiNeurobiology Group, Division of Biochemical Sciences, CSIR-National Chemical LaboratoryDr Homi Bhabha RoadPune411008India[email protected]Academy of Scientific and Innovative Research (AcSIR)Ghaziabad201002IndiaSearch for other works by this author on:
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Chapter 7: Role of Metal Ions in Alzheimer's Disease: Mechanistic Aspects Contributing to Neurotoxicityp170-192ByC. HureauC. HureauSearch for other works by this author on:
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Chapter 8: Microglial Blockade of the Amyloid Cascade: A New Therapeutic Frontierp193-254ByDavid V. Hansen;David V. HansenBrigham Young University, Department of Chemistry and BiochemistryC212 BNSNProvoUT 84602USA[email protected]Search for other works by this author on:Brenan K. Cullimore;Brenan K. CullimoreBrigham Young University, Department of Chemistry and BiochemistryC212 BNSNProvoUT 84602USA[email protected]Search for other works by this author on:John C. Johanson;John C. JohansonBrigham Young University, Department of Chemistry and BiochemistryC212 BNSNProvoUT 84602USA[email protected]Search for other works by this author on:Wenhan ChengWenhan ChengBrigham Young University, Department of Chemistry and BiochemistryC212 BNSNProvoUT 84602USA[email protected]Search for other works by this author on:
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Chapter 9: Post-translational Modifications and Alzheimer's Diseasep255-286ByDikshaa Padhi;Dikshaa PadhiBioorganic Chemistry Laboratory, New Chemistry Unit Jawaharlal Nehru Centre for Advanced Scientific Research (JNCASR)Jakkur P.O.Bengaluru 560064KarnatakaIndia[email protected]Search for other works by this author on:Madhu Ramesh;Madhu RameshBioorganic Chemistry Laboratory, New Chemistry Unit Jawaharlal Nehru Centre for Advanced Scientific Research (JNCASR)Jakkur P.O.Bengaluru 560064KarnatakaIndia[email protected]Search for other works by this author on:Thimmaiah GovindarajuThimmaiah GovindarajuBioorganic Chemistry Laboratory, New Chemistry Unit Jawaharlal Nehru Centre for Advanced Scientific Research (JNCASR)Jakkur P.O.Bengaluru 560064KarnatakaIndia[email protected]Search for other works by this author on:
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Chapter 10: Autophagy: Role in Alzheimer's Disease Pathophysiology and Therapeutic Avenuesp287-328ByNaqiya Ambareen;Naqiya AmbareenCell Biology and Physiology Division, CSIR-Indian Institute of Chemical Biology4 Raja S. C. Mullick RoadKolkata 700 032India[email protected][email protected]Academy of Scientific and Innovative Research (AcSIR), Headquarters, CSIR-HRDC campus, sector 19Kamla Nehru NagarGhaziabad-201002IndiaSearch for other works by this author on:Sukanya Sarkar;Sukanya SarkarCell Biology and Physiology Division, CSIR-Indian Institute of Chemical Biology4 Raja S. C. Mullick RoadKolkata 700 032India[email protected][email protected]Search for other works by this author on:Akash Saha;Akash SahaCell Biology and Physiology Division, CSIR-Indian Institute of Chemical Biology4 Raja S. C. Mullick RoadKolkata 700 032India[email protected][email protected]Search for other works by this author on:Subhas C. BiswasSubhas C. BiswasCell Biology and Physiology Division, CSIR-Indian Institute of Chemical Biology4 Raja S. C. Mullick RoadKolkata 700 032India[email protected][email protected]Academy of Scientific and Innovative Research (AcSIR), Headquarters, CSIR-HRDC campus, sector 19Kamla Nehru NagarGhaziabad-201002IndiaSearch for other works by this author on:
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Chapter 11: Transmission of Pathogenic Proteins and the Role of Microbial Infection in Alzheimer's Disease Pathologyp329-353ByAkanksha Mishra;Akanksha MishraBioorganic Chemistry Laboratory, New Chemistry Unit, Jawaharlal Nehru Centre for Advanced Scientific Research (JNCASR)Jakkur P.O.Bengaluru 560064KarnatakaIndia[email protected]Search for other works by this author on:Madhu Ramesh;Madhu RameshBioorganic Chemistry Laboratory, New Chemistry Unit, Jawaharlal Nehru Centre for Advanced Scientific Research (JNCASR)Jakkur P.O.Bengaluru 560064KarnatakaIndia[email protected]Search for other works by this author on:Thimmaiah GovindarajuThimmaiah GovindarajuBioorganic Chemistry Laboratory, New Chemistry Unit, Jawaharlal Nehru Centre for Advanced Scientific Research (JNCASR)Jakkur P.O.Bengaluru 560064KarnatakaIndia[email protected]Search for other works by this author on:
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Chapter 12: The Role of Gut Microbiome in Alzheimer's Disease and Therapeutic Strategiesp354-376BySourav Samanta;Sourav SamantaBioorganic Chemistry laboratory, New Chemistry Unit, Jawaharlal Nehru Centre for Advanced Scientific Research (JNCASR)Bengaluru 560064India[email protected]Search for other works by this author on:Madhu Ramesh;Madhu RameshBioorganic Chemistry laboratory, New Chemistry Unit, Jawaharlal Nehru Centre for Advanced Scientific Research (JNCASR)Bengaluru 560064India[email protected]Search for other works by this author on:Ashish Kumar;Ashish KumarBioorganic Chemistry laboratory, New Chemistry Unit, Jawaharlal Nehru Centre for Advanced Scientific Research (JNCASR)Bengaluru 560064India[email protected]Search for other works by this author on:Thimmaiah GovindarajuThimmaiah GovindarajuBioorganic Chemistry laboratory, New Chemistry Unit, Jawaharlal Nehru Centre for Advanced Scientific Research (JNCASR)Bengaluru 560064India[email protected]Search for other works by this author on:
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Chapter 13: Molecular Probes for the Diagnosis of Alzheimer's Disease with Implications for Multiplexed and Multimodal Strategiesp377-414ByMadhu Ramesh;Madhu RameshBioorganic Chemistry Laboratory, New Chemistry Unit, Jawaharlal Nehru Centre for Advanced Scientific ResearchJakkur P.O.Bengaluru560064 KarnatakaIndia[email protected]Search for other works by this author on:Sourav Samanta;Sourav SamantaBioorganic Chemistry Laboratory, New Chemistry Unit, Jawaharlal Nehru Centre for Advanced Scientific ResearchJakkur P.O.Bengaluru560064 KarnatakaIndia[email protected]Search for other works by this author on:Thimmaiah GovindarajuThimmaiah GovindarajuBioorganic Chemistry Laboratory, New Chemistry Unit, Jawaharlal Nehru Centre for Advanced Scientific ResearchJakkur P.O.Bengaluru560064 KarnatakaIndia[email protected]VNIR Biotechnologies Pvt. Ltd., Bangalore Bioinnovation Center, Helix Biotech ParkElectronic City Phase IBengaluru 560100KarnatakaIndiaSearch for other works by this author on:
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Chapter 14: Circulating Biomarkers for the Diagnosis of Alzheimer's Diseasep415-441BySiranjeevi Nagaraj;Siranjeevi NagarajBioorganic Chemistry Laboratory, New Chemistry Unit, Jawaharlal Nehru Centre for Advanced Scientific Research (JNCASR)Jakkur P.O.Bengaluru 560064KarnatakaIndia[email protected]Search for other works by this author on:Madhu Ramesh;Madhu RameshBioorganic Chemistry Laboratory, New Chemistry Unit, Jawaharlal Nehru Centre for Advanced Scientific Research (JNCASR)Jakkur P.O.Bengaluru 560064KarnatakaIndia[email protected]Search for other works by this author on:Thimmaiah GovindarajuThimmaiah GovindarajuBioorganic Chemistry Laboratory, New Chemistry Unit, Jawaharlal Nehru Centre for Advanced Scientific Research (JNCASR)Jakkur P.O.Bengaluru 560064KarnatakaIndia[email protected]Search for other works by this author on:
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Chapter 15: Lactoferrin: A Potential Theranostic Candidate for Alzheimer's Diseasep442-454ByMadhu Ramesh;Madhu RameshBioorganic Chemistry Laboratory, New Chemistry Unit, Jawaharlal Nehru Centre for Advanced Scientific Research (JNCASR)Jakkur P.O.Bengaluru 560064KarnatakaIndia[email protected]Search for other works by this author on:Thimmaiah GovindarajuThimmaiah GovindarajuBioorganic Chemistry Laboratory, New Chemistry Unit, Jawaharlal Nehru Centre for Advanced Scientific Research (JNCASR)Jakkur P.O.Bengaluru 560064KarnatakaIndia[email protected]Search for other works by this author on:
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Chapter 16: Multifunctional Inhibitors of Multifaceted Aβ Toxicity of Alzheimer's Diseasep455-486ByTanmay Mondal;Tanmay MondalBioorganic Chemistry Laboratory, New Chemistry Unit, Jawaharlal Nehru Centre for Advanced Scientific ResearchJakkur P. O.Bengaluru 560064KarnatakaIndia[email protected]Search for other works by this author on:Sourav Samanta;Sourav SamantaBioorganic Chemistry Laboratory, New Chemistry Unit, Jawaharlal Nehru Centre for Advanced Scientific ResearchJakkur P. O.Bengaluru 560064KarnatakaIndia[email protected]Search for other works by this author on:Ashish Kumar;Ashish KumarBioorganic Chemistry Laboratory, New Chemistry Unit, Jawaharlal Nehru Centre for Advanced Scientific ResearchJakkur P. O.Bengaluru 560064KarnatakaIndia[email protected]Search for other works by this author on:Thimmaiah GovindarajuThimmaiah GovindarajuBioorganic Chemistry Laboratory, New Chemistry Unit, Jawaharlal Nehru Centre for Advanced Scientific ResearchJakkur P. O.Bengaluru 560064KarnatakaIndia[email protected]Search for other works by this author on:
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Chapter 17: Tau-targeting Therapeutic Strategies for Alzheimer's Diseasep487-514ByPushparathinam Gopinath;Pushparathinam GopinathDepartment of Chemistry, SRM-Institute of Science and TechnologyKattankulathur603203 ChennaiTamilnaduIndia[email protected]Search for other works by this author on:Madhu Ramesh;Madhu RameshBioorganic Chemistry Laboratory, New Chemistry Unit, Jawaharlal Nehru Centre for Advanced Scientific Research (JNCASR)Jakkur P.O.Bengaluru 560064KarnatakaIndia[email protected]Search for other works by this author on:Thimmaiah GovindarajuThimmaiah GovindarajuBioorganic Chemistry Laboratory, New Chemistry Unit, Jawaharlal Nehru Centre for Advanced Scientific Research (JNCASR)Jakkur P.O.Bengaluru 560064KarnatakaIndia[email protected]Search for other works by this author on:
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Chapter 18: Computational Development of Alzheimer's Therapeutics and Diagnosticsp515-551ByN. Arul Murugan;N. Arul MuruganaDepartment of Computer Science, School of Electrical Engineering and Computer Science, Royal Institute of Technology (KTH), AlbaNova University CenterS-106 91StockholmSweden[email protected][email protected][email protected]Search for other works by this author on:Chitra Jeyaraj Pandian;Chitra Jeyaraj PandianDepartment of Biotechnology, Dr. Umayal Ramanathan College for WomenKaraikudiIndiaSearch for other works by this author on:Jeba Mercy Jeyaseelan;Jeba Mercy JeyaseelanDepartment of Biotechnology, Dr. Umayal Ramanathan College for WomenKaraikudiIndiaSearch for other works by this author on:S. Muneeswaran;S. MuneeswaranChemical Biology and Biophysics Laboratory, Department of Physical Chemistry, School of Chemistry, Madurai Kamaraj UniversityPalkalai NagarMadurai-625021IndiaSearch for other works by this author on:K. Saranraj;K. SaranrajChemical Biology and Biophysics Laboratory, Department of Physical Chemistry, School of Chemistry, Madurai Kamaraj UniversityPalkalai NagarMadurai-625021IndiaSearch for other works by this author on:K. Muruga Poopathi Raja;K. Muruga Poopathi RajaChemical Biology and Biophysics Laboratory, Department of Physical Chemistry, School of Chemistry, Madurai Kamaraj UniversityPalkalai NagarMadurai-625021IndiaSearch for other works by this author on:J. JeyakanthanJ. JeyakanthanDepartment of Bioinformatics, Alagappa UniversityKaraikudiTamilnaduIndiaSearch for other works by this author on:
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Chapter 19: Targeted Protein Degradation as a Therapeutic Avenue for Alzheimer's Diseasep552-577ByBhubaneswar MandalBhubaneswar MandalSearch for other works by this author on:
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Chapter 20: Cell-based Therapy for Alzheimer's Diseasep578-590ByG. Guarnieri;G. GuarnieriSection of Human Anatomy and Histology, Department of Experimental and Clinical Medicine, University of Florence50134 FlorenceItaly[email protected]Search for other works by this author on:E. Sarchielli;E. SarchielliSection of Human Anatomy and Histology, Department of Experimental and Clinical Medicine, University of Florence50134 FlorenceItaly[email protected]Search for other works by this author on:P. Gallina;P. GallinaNeurosurgical Unit, Department of Neurosciences, Psychology, Drug Research and Child Health, University of Florence50134 FlorenceItalySearch for other works by this author on:A. MorelliA. MorelliSection of Human Anatomy and Histology, Department of Experimental and Clinical Medicine, University of Florence50134 FlorenceItaly[email protected]Search for other works by this author on:
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Chapter 21: Experimental Models to Study Alzheimer's Diseasep591-607ByAkanksha Mishra;Akanksha MishraDivision of Neuroscience and Ageing biology, CSIR- Central Drug Research InstituteSector 10, Jankipuram Extension, Sitapur RoadLucknow-226031(U.P.)India[email protected]Department of Cell Biology and Anatomy, New York Medical CollegeValhallaNY 01595USASearch for other works by this author on:Virendra Tiwari;Virendra TiwariDivision of Neuroscience and Ageing biology, CSIR- Central Drug Research InstituteSector 10, Jankipuram Extension, Sitapur RoadLucknow-226031(U.P.)India[email protected]Academy of Scientific and Innovative Research (AcSIR)Ghaziabad-201002IndiaSearch for other works by this author on:Sonu Singh;Sonu SinghDivision of Neuroscience and Ageing biology, CSIR- Central Drug Research InstituteSector 10, Jankipuram Extension, Sitapur RoadLucknow-226031(U.P.)India[email protected]Department of Neuroscience, School of MedicineRoom- L4078, Uconn Health, 263 Farmington AvenueFarmingtonCT-06030USASearch for other works by this author on:Shubha ShuklaShubha ShuklaDivision of Neuroscience and Ageing biology, CSIR- Central Drug Research InstituteSector 10, Jankipuram Extension, Sitapur RoadLucknow-226031(U.P.)India[email protected]Academy of Scientific and Innovative Research (AcSIR)Ghaziabad-201002IndiaSearch for other works by this author on:
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Chapter 22: Ethnic and Racial Differences in The Pathophysiology of Alzheimer's Diseasep608-659ByPavani Rekulapally;Pavani RekulapallyCentre for Brain Research (CBR), Indian Institute of Science (IISc)Bangalore-560012India[email protected][email protected]College of Medical, Veterinary and Life Sciences (MVLS), University of GlasgowUnited KingdomSearch for other works by this author on:Lakshmi Garimella;Lakshmi GarimellaMolecular Biology and Genetic Unit (MBGU), Jawaharlal Nehru Centre for Advanced Scientific Research (JNCASR)Bangalore-560064IndiaSearch for other works by this author on:Saravanan Krishnan;Saravanan KrishnanFormulation Research and Development Dhanvantari Nano Ayushadi Pvt LtdChennai-603017IndiaCreative Carbon Labs (C2L), TICEL biopark limitedChennai-600113IndiaSearch for other works by this author on:N. Ashwin Kumar;N. Ashwin KumarDepartment of Biomedical Engineering, SRM Institute of Science and TechnologyChennai-603203IndiaSearch for other works by this author on:S. N. SureshS. N. SureshCentre for Brain Research (CBR), Indian Institute of Science (IISc)Bangalore-560012India[email protected][email protected]Institute of Brain Science (IBS), TICEL biopark limitedChennai-600113IndiaSearch for other works by this author on:
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